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Tbio
KIF19
Kinesin-like protein KIF19

Protein Summary
Description
Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389916
  • ENSP00000374566
  • ENSG00000196169

Symbol
  • KIF19A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
cellular component
0.61
cell line
0.6
protein domain
0.58
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.48   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (115)
1 – 10 of 115
KIFC1
Tchem
Novelty:  0.00982095
Score:  0.948
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.946
Data Source:  STRINGDB
CENPE
Tchem
Novelty:  0.00458125
Score:  0.945
Data Source:  STRINGDB
KIFC2
Tbio
Novelty:  0.10989267
Score:  0.941
Data Source:  STRINGDB
KIF4B
Tbio
Novelty:  0.48684333
Score:  0.941
Data Source:  STRINGDB
KIF25
Tbio
Novelty:  0.17030283
Score:  0.938
Data Source:  STRINGDB
KIF4A
Tbio
Novelty:  0.00888393
Score:  0.937
Data Source:  STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.934
Data Source:  STRINGDB
KIF2A
Tbio
Novelty:  0.01463006
Score:  0.928
Data Source:  STRINGDB
KIF23
Tbio
Novelty:  0.00719651
Score:  0.927
Data Source:  STRINGDB
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
70.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2447024
286942
Rat
RGD:1559936
303659
Dog
kinesin family member 19
VGNC:42389
483285
Horse
kinesin family member 19
VGNC:19400
100060836
Cow
kinesin family member 19
VGNC:30589
538109
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
kinesin family member 19
Horse
kinesin family member 19
Cow
kinesin family member 19
Publication Statistics
PubMed Score 5.48
PubMed score by year
PubTator Score 2.63
PubTator score by year