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Tdark
CCDC57
Coiled-coil domain-containing protein 57

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389641
  • ENSP00000374292
  • ENSG00000176155
  • ENST00000392343
  • ENSP00000376154
  • ENST00000392347
  • ENSP00000376158
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
transcription factor
0.81
histone modification site profile
0.74
virus perturbation
0.64
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.77   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.999999844
p_ni:  1e-9
p_wrong:  1.55e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.769
Data Source:  STRINGDB
BRI3BP
Tbio
Novelty:  0.14998786
Score:  0.706
Data Source:  STRINGDB
GLT6D1
Tbio
Family:  Enzyme
Novelty:  0.14285349
Score:  0.691
Data Source:  STRINGDB
SFI1
Tdark
Novelty:  0.01943587
Score:  0.686
Data Source:  STRINGDB
OR6T1
Tdark
Family:  oGPCR
Novelty:  35
Score:  0.587
Data Source:  STRINGDB
ZNF341
Tdark
Family:  TF
Novelty:  0.51833913
Score:  0.562
Data Source:  STRINGDB
HEATR9
Tdark
Novelty:  0.71415315
Score:  0.541
Data Source:  STRINGDB
PIGU
Tbio
Novelty:  0.11800036
Score:  0.498
Data Source:  STRINGDB
C17orf78
Tdark
Novelty:  4.29271752
Score:  0.493
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
4
5
74.9
serum urea measurement
1
1
1
70.2
blood metabolite measurement
1
1
1
57.3
blood urea nitrogen measurement
1
1
1
42.3
body mass index
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
74.9
serum urea measurement
1
70.2
blood metabolite measurement
1
57.3
blood urea nitrogen measurement
1
42.3
body mass index
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 57
719405
Mouse
MGI:1918526
71276
Rat
Dog
coiled-coil domain containing 57
VGNC:38843
607741
Horse
coiled-coil domain containing 57
VGNC:51396
102149730
Species
Name
OMA
EggNOG
Inparanoid
Macaque
coiled-coil domain containing 57
Mouse
Rat
Dog
coiled-coil domain containing 57
Horse
coiled-coil domain containing 57
Publication Statistics
PubMed Score 3.77
PubMed score by year
PubTator Score 1.56
PubTator score by year
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Related Publications
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PMID
Year
Title