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Tbio
ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Protein Summary
Description
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain. This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000521508
  • ENSP00000430236
  • ENSG00000253710

Symbol
  • GT8
  • GT8
  • CDG1P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
transcription factor binding site profile
0.65
tissue sample
0.62
pathway
0.6
virus perturbation
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG11, alpha-1,2-mannosyltransferase
VGNC:9786
452735
Mouse
MGI:2142632
207958
Rat
RGD:1564725
361174
Dog
ALG11, alpha-1,2-mannosyltransferase
VGNC:37794
100682632
Horse
ALG11, alpha-1,2-mannosyltransferase
VGNC:15245
100049892
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG11, alpha-1,2-mannosyltransferase
Mouse
Rat
Dog
ALG11, alpha-1,2-mannosyltransferase
Horse
ALG11, alpha-1,2-mannosyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2TAA5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG11 causes ALG11-CDG (CDG-1p)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG11 causes ALG11-CDG (CDG-1p)
Disease
Diseases associated with N-glycosylation of proteins
Protein-Protein Interactions (114)
1 – 10 of 114
HAUS7
Tbio
Novelty: 1.11657571
p_int: 0.984760119
p_ni: 0.015239881
Score: 0.181
Data Source: BioPlex,STRINGDB
RAET1E
Tbio
Novelty: 0.01859274
p_int: 0.880678399
p_ni: 0.119321601
Score: 0.189
Data Source: BioPlex,STRINGDB
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.856461426
p_ni: 0.143537954
p_wrong: 6.2e-7
Data Source: BioPlex
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
p_int: 0.843244319
p_ni: 0.156755681
Data Source: BioPlex
TMEM213
Tdark
Novelty: 0.87036241
p_int: 0.842723181
p_ni: 0.157276819
Score: 0.334
Data Source: BioPlex,STRINGDB
PVR
Tbio
Novelty: 0.00215811
p_int: 0.836296559
p_ni: 0.163703441
Score: 0.179
Data Source: BioPlex,STRINGDB
TSPAN31
Tbio
Novelty: 0.13580467
p_int: 0.801908807
p_ni: 0.198091188
p_wrong: 5e-9
Data Source: BioPlex
ALG3
Tbio
Family: Enzyme
Novelty: 0.0159047
Score: 0.987
Data Source: STRINGDB
RFT1
Tbio
Novelty: 6.81081081
Score: 0.965
Data Source: STRINGDB
ALG2
Tbio
Family: Enzyme
Novelty: 0.03804805
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  113.66

PubMed score by year
PubTator Score  10.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer