You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIM71
E3 ubiquitin-protein ligase TRIM71

Protein Summary
Description
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). The protein encoded by this gene is an E3 ubiquitin-prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383763
  • ENSP00000373272
  • ENSG00000206557

Symbol
  • LIN41
  • LIN41
  • LIN-41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.73
molecular function
0.67
histone modification site profile
0.59
ligand (protein) perturbation
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.28   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.28   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
82.9
cup-to-disc ratio measurement
2
2
2
71.8
2
2
0
1.1
37.5
1
1
0
1.1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
82.9
cup-to-disc ratio measurement
2
71.8
0
1.1
37.5
0
1.1
3.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 71
705341
Mouse
MGI:2685973
636931
Rat
RGD:1566388
301042
Dog
tripartite motif containing 71
VGNC:47837
477014
Cow
E3 ubiquitin-protein ligase TRIM71 [Source:UniProtKB/Swiss-Prot;Acc:E1BJS7]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 71
Mouse
Rat
Dog
tripartite motif containing 71
Cow
E3 ubiquitin-protein ligase TRIM71 [Source:UniProtKB/Swiss-Prot;Acc:E1BJS7]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2Q1W2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (86)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (309)
1 – 10 of 309
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.99985166
p_ni:  0.00014834
Data Source:  BioPlex
E4F1
Tbio
Family:  TF
Novelty:  0.02192338
p_int:  0.999793006
p_ni:  0.000206994
Score:  0.157
Data Source:  BioPlex,STRINGDB
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.999587535
p_ni:  0.000412465
p_wrong:  1e-9
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999289394
p_ni:  0.000710091
p_wrong:  5.15e-7
Data Source:  BioPlex
THAP2
Tdark
Family:  TF
Novelty:  0.21339518
p_int:  0.998203274
p_ni:  0.001796726
Score:  0.252
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.997458456
p_ni:  0.002541544
Score:  0.232
Data Source:  BioPlex,STRINGDB
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.995647632
p_ni:  0.004352368
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.991673227
p_ni:  0.008326773
Data Source:  BioPlex
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.987930411
p_ni:  0.012069588
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.980639895
p_ni:  0.019328415
p_wrong:  0.00003169
Data Source:  BioPlex
Publication Statistics
PubMed Score  97.28

PubMed score by year
PubTator Score  16.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: