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Tdark
RALGAPA2
Ral GTPase-activating protein subunit alpha-2

Protein Summary
Description
Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202677
  • ENSP00000202677
  • ENSG00000188559

Symbol
  • C20orf74
  • KIAA1272
  • p220
  • AS250
  • C20orf74
  • dJ1049G11
  • bA287B20.1
  • dJ1049G11.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
histone modification site profile
0.74
transcription factor
0.74
transcription factor perturbation
0.74
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.81   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.81   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
NKIRAS2
Tbio
Family:  Enzyme
Novelty:  0.11182522
p_int:  0.999999995
p_ni:  5e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.99999998
p_ni:  2e-8
Score:  0.734
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999999898
p_ni:  1.02e-7
Data Source:  BioPlex
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
p_int:  0.99995592
p_ni:  0.000044069
p_wrong:  1e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
MTMR7
Tbio
Family:  Enzyme
Novelty:  0.1707096
p_int:  0.999946442
p_ni:  0.000053558
Score:  0.346
Data Source:  BioPlex,STRINGDB
RALGAPB
Tbio
Family:  Enzyme
Novelty:  0.31941838
Score:  0.96
Data Source:  Reactome,STRINGDB
RALA
Tbio
Family:  Enzyme
Novelty:  0.00257914
Score:  0.941
Data Source:  STRINGDB
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
Score:  0.919
Data Source:  Reactome,STRINGDB
FYB2
Tbio
Novelty:  1.466412
Score:  0.578
Data Source:  STRINGDB
RIN2
Tbio
Novelty:  0.0527887
Score:  0.568
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
2
2
58.3
diet measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
2
58.3
diet measurement
1
4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein catalytic alpha subunit 2
VGNC:9946
458128
Macaque
Ral GTPase activating protein catalytic alpha subunit 2
700311
Mouse
MGI:3036245
241694
Rat
RGD:1308023
296211
Dog
Ral GTPase activating protein catalytic alpha subunit 2
VGNC:45333
485747
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein catalytic alpha subunit 2
Macaque
Ral GTPase activating protein catalytic alpha subunit 2
Mouse
Rat
Dog
Ral GTPase activating protein catalytic alpha subunit 2
Publication Statistics
PubMed Score 7.81
PubMed score by year
PubTator Score 12.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title