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Tbio
TCTN1
Tectonic-1

Protein Summary
Description
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity). This gene encodes a member of a family of secreted and transmembrane proteins. The orthologous gene in mouse functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. This protein is a component of the tectonic-like complex, which forms a barrier between the ciliary ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397655
  • ENSP00000380775
  • ENSG00000204852
  • ENST00000397659
  • ENSP00000380779
  • ENST00000551590
  • ENSP00000448735

Symbol
  • TECT1
  • TECT1
  • JBTS13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cellular component
0.72
small molecule perturbation
0.63
tissue sample
0.63
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
CC2D2A
Tbio
Novelty:  0.03684487
p_int:  0.999998765
p_ni:  0.000001229
p_wrong:  7e-9
Score:  0.987
Data Source:  BioPlex,STRINGDB
TMEM231
Tbio
Novelty:  0.17100188
p_int:  0.999948231
p_ni:  0.000051769
Score:  0.967
Data Source:  BioPlex,STRINGDB
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.999820231
p_ni:  0.000179769
Data Source:  BioPlex
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.995911162
p_ni:  0.004088838
Data Source:  BioPlex
MKS1
Tbio
Novelty:  0.02463305
p_int:  0.988704339
p_ni:  0.011295661
Score:  0.975
Data Source:  BioPlex,STRINGDB
SMOC1
Tbio
Novelty:  0.03819681
p_int:  0.979389
p_ni:  0.019378685
p_wrong:  0.001232315
Data Source:  BioPlex
MICA
Tbio
Novelty:  0.03965901
p_int:  0.96814969
p_ni:  0.031849322
p_wrong:  9.88e-7
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.963854228
p_ni:  0.035773274
p_wrong:  0.000372498
Data Source:  BioPlex
CST9L
Tdark
Novelty:  0.21941207
p_int:  0.96311021
p_ni:  0.035814313
p_wrong:  0.001075477
Data Source:  BioPlex
B9D2
Tbio
Novelty:  0.11310836
p_int:  0.948150263
p_ni:  0.051802561
p_wrong:  0.000047176
Score:  0.995
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 1
VGNC:5615
736949
Mouse
MGI:3603820
654470
Rat
RGD:1566266
304486
Dog
tectonic family member 1
VGNC:47213
100686623
Horse
tectonic family member 1
VGNC:23967
100058201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectonic family member 1
Mouse
Rat
Dog
tectonic family member 1
Horse
tectonic family member 1
Publication Statistics
PubMed Score 18.24
PubMed score by year
PubTator Score 11.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title