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Tbio
RSPO1
R-spondin-1

Protein Summary
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805). This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repea ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356545
  • ENSP00000348944
  • ENSG00000169218
  • ENST00000401068
  • ENSP00000383846
  • ENST00000612451
  • ENSP00000479832
  • ENST00000615459
  • ENSP00000481178

Symbol
  • RSPO
  • CRISTIN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.61
cell line
0.6
gene perturbation
0.6
cell type or tissue
0.57
PubMedID
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.22   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.22   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
1
4
97.6
Malignant epithelial tumor of ovary
1
1
0
1.1
65.9
intraocular pressure measurement
2
1
2
59.6
1
1
0
1.1
53.5
balding measurement
1
1
1
9.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
97.6
Malignant epithelial tumor of ovary
0
1.1
65.9
intraocular pressure measurement
2
59.6
0
1.1
53.5
balding measurement
1
9.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
R-spondin 1
VGNC:6988
469283
Macaque
R-spondin 1
713976
Mouse
MGI:2183426
192199
Rat
RGD:1565558
313589
Dog
R-spondin 1
VGNC:45782
608179
Species
Name
OMA
EggNOG
Inparanoid
Chimp
R-spondin 1
Macaque
R-spondin 1
Mouse
Rat
Dog
R-spondin 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q2MKA7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (117)
1 – 10 of 117
LACRT
Tbio
Novelty: 0.03333799
p_int: 0.925771551
p_ni: 0.069407102
p_wrong: 0.004821347
Data Source: BioPlex
CHTOP
Tbio
Novelty: 0.04170391
p_int: 0.897010672
p_ni: 0.102989328
Score: 0.254
Data Source: BioPlex,STRINGDB
ZNF579
Tdark
Family: TF
Novelty: 4.75515836
p_int: 0.877568616
p_ni: 0.122424754
p_wrong: 0.00000663
Score: 0.222
Data Source: BioPlex,STRINGDB
HECTD3
Tdark
Family: Enzyme
Novelty: 2.20874654
p_int: 0.797678589
p_ni: 0.202321411
Score: 0.167
Data Source: BioPlex,STRINGDB
CEP76
Tdark
Novelty: 0.3880387
p_int: 0.765755989
p_ni: 0.233593253
p_wrong: 0.000650758
Score: 0.226
Data Source: BioPlex,STRINGDB
C1QBP
Tbio
Novelty: 0.00532825
p_int: 0.765030273
p_ni: 0.234969727
Data Source: BioPlex
ZZEF1
Tdark
Novelty: 0.33216648
p_int: 0.759688525
p_ni: 0.240311463
p_wrong: 1.2e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
RNF43
Tbio
Family: Enzyme
Novelty: 0.01258908
Score: 0.998
Data Source: Reactome,STRINGDB
LGR4
Tbio
Family: GPCR
Novelty: 0.01180123
Score: 0.998
Data Source: Reactome,STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.997
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  273.22

PubMed score by year
PubTator Score  111.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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