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Tbio
HYAL4
Hyaluronidase-4

Protein Summary
Description
Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223026
  • ENSP00000223026
  • ENSG00000106302
  • ENST00000476325
  • ENSP00000417186

Symbol
  • CSHY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
protein domain
0.58
gene perturbation
0.57
cell line
0.5
tissue
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.89   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
5
4
4.1
97.5
platelet crit
2
4
4
95.3
mean platelet volume
3
4
4
93.6
reticulocyte count
4
5
6
91.4
reticulocyte measurement
2
3
4
84.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
4.1
97.5
platelet crit
4
95.3
mean platelet volume
4
93.6
reticulocyte count
6
91.4
reticulocyte measurement
4
84.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyaluronoglucosaminidase 4
VGNC:14026
472497
Macaque
hyaluronidase-4
696128
Mouse
MGI:1924292
77042
Rat
RGD:1303194
404783
Dog
hyaluronoglucosaminidase 4
VGNC:41844
475212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyaluronoglucosaminidase 4
Macaque
hyaluronidase-4
Mouse
Rat
Dog
hyaluronoglucosaminidase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2M3T9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (34)
1 – 10 of 34
GAPDHS
Tbio
Family:  Enzyme
Novelty:  0.00885959
p_int:  0.960097116
p_ni:  0.039902877
p_wrong:  7e-9
Score:  0.351
Data Source:  BioPlex,STRINGDB
GALNS
Tbio
Family:  Enzyme
Novelty:  0.00510529
Score:  0.943
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.929
Data Source:  STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.928
Data Source:  STRINGDB
IDUA
Tbio
Family:  Enzyme
Novelty:  0.00288117
Score:  0.912
Data Source:  STRINGDB
GRM8
Tchem
Family:  GPCR
Novelty:  0.00827879
Score:  0.642
Data Source:  STRINGDB
HAS2
Tbio
Family:  Enzyme
Novelty:  0.0025539
Score:  0.639
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.625
Data Source:  STRINGDB
HAS1
Tbio
Family:  Enzyme
Novelty:  0.02014779
Score:  0.572
Data Source:  STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.57
Data Source:  STRINGDB
Publication Statistics
PubMed Score  7.89

PubMed score by year
PubTator Score  3.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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