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Tdark
SHROOM1
Protein Shroom1

Protein Summary
Description
May be involved in the assembly of microtubule arrays during cell elongation. SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319854
  • ENSP00000324245
  • ENSG00000164403
  • ENST00000378679
  • ENSP00000367950
  • ENST00000617339
  • ENSP00000478436

Symbol
  • APXL2
  • KIAA1960
  • APXL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
transcription factor
0.58
transcription factor binding site profile
0.55
histone modification site profile
0.53
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.34   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (24)
1 – 10 of 24
NYX
Tbio
Novelty: 0.0100148
p_int: 0.999702108
p_ni: 0.000142935
p_wrong: 0.000154958
Score: 0.54
Data Source: BioPlex,STRINGDB
SOWAHA
Tdark
Novelty: 1.30261993
Score: 0.726
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.629
Data Source: STRINGDB
SMIM5
Tdark
Novelty: 2.35647741
Score: 0.53
Data Source: STRINGDB
PHLDB3
Tdark
Novelty: 2.01921901
Score: 0.522
Data Source: STRINGDB
FANK1
Tbio
Novelty: 0.12389783
Score: 0.518
Data Source: STRINGDB
PRSS48
Tdark
Family: Enzyme
Novelty: 3.46227013
Score: 0.515
Data Source: STRINGDB
UBXN8
Tbio
Novelty: 0.12560109
Score: 0.506
Data Source: STRINGDB
GRXCR2
Tbio
Novelty: 0.49452902
Score: 0.502
Data Source: STRINGDB
OR11G2
Tdark
Family: oGPCR
Novelty: 10.92587413
Score: 0.471
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.34

PubMed score by year
PubTator Score  2.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer