Tdark SHROOM1 Protein Shroom1

Protein Summary

Description

May be involved in the assembly of microtubule arrays during cell elongation. SHROOM family members play diverse roles in the development of the nervous system and other tissues (Hagens et al., 2006 [PubMed 16615870]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q2M3G4
• B7WP40
• B7ZL01
• Q8TDP0
• Q8TF41

Gene Name

• SHROOM1

Ensembl ID

• ENST00000319854
• ENSP00000324245
• ENSG00000164403
• ENST00000378679
• ENSP00000367950
• ENST00000617339
• ENSP00000478436

Symbol

• APXL2
• KIAA1960
• APXL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.65
transcription factor	0.58
transcription factor binding site profile	0.55
histone modification site profile	0.53
cell type or tissue	0.52

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Protein Shroom1

Protein / Receptor / Ligand-gated Ion Channel / Protein Shroom1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.36   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.36   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0