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Tbio
ABCB5
ATP-binding cassette sub-family B member 5

Protein Summary
Description
Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair. ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258738
  • ENSP00000258738
  • ENSG00000004846
  • ENST00000404938
  • ENSP00000384881
  • ENST00000406935
  • ENSP00000383899
  • ENST00000443026
  • ENSP00000406730

Symbol
  • ABCB5beta
  • EST422562
  • ABCB5alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.73
tissue
0.56
cell line
0.55
microRNA
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.9   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.9   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
PPP1R15B
Tchem
Family:  Enzyme
Novelty:  0.0244819
p_int:  0.926060978
p_ni:  0.027844132
p_wrong:  0.046094889
Score:  0.403
Data Source:  BioPlex,STRINGDB
ABCE1
Tbio
Family:  Transporter
Novelty:  0.00529126
Score:  0.733
Data Source:  STRINGDB
PROM1
Tbio
Novelty:  0.00037987
Score:  0.678
Data Source:  STRINGDB
SLC22A14
Tdark
Family:  Transporter
Novelty:  0.3340737
Score:  0.66
Data Source:  STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.646
Data Source:  STRINGDB
KDM5B
Tchem
Family:  TF; Epigenetic
Novelty:  0.00610414
Score:  0.591
Data Source:  STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.585
Data Source:  STRINGDB
CTIF
Tbio
Novelty:  0.0764323
Score:  0.584
Data Source:  STRINGDB
SLCO6A1
Tbio
Family:  Transporter
Novelty:  0.07836028
Score:  0.582
Data Source:  STRINGDB
SLCO5A1
Tbio
Family:  Transporter
Novelty:  0.17025746
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
0
1.1
85.4
eosinophil count
1
1
1
34.9
alcohol consumption measurement
3
1
3
33.1
alcohol use disorder measurement
1
1
1
33.1
eosinophil percentage of leukocytes
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.4
eosinophil count
1
34.9
alcohol consumption measurement
3
33.1
alcohol use disorder measurement
1
33.1
eosinophil percentage of leukocytes
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 5
VGNC:4242
743269
Macaque
ATP binding cassette subfamily B member 5
712883
Mouse
MGI:1924956
77706
Rat
RGD:1566342
314537
Dog
ATP binding cassette subfamily B member 5
VGNC:49905
482344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily B member 5
Macaque
ATP binding cassette subfamily B member 5
Mouse
Rat
Dog
ATP binding cassette subfamily B member 5
Publication Statistics
PubMed Score 206.90
PubMed score by year
PubTator Score 68.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title