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Tdark
TMEM266
Transmembrane protein 266

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388942
  • ENSP00000373594
  • ENSG00000169758

Symbol
  • C15orf27
  • HVRP1
  • C15orf27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
4
5
98
glomerular filtration rate
5
5
6
98
urate measurement
4
5
6
97.9
hemoglobin measurement
3
3
4
97.1
creatinine measurement
2
3
3
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
5
98
glomerular filtration rate
6
98
urate measurement
6
97.9
hemoglobin measurement
4
97.1
creatinine measurement
3
89
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 266
VGNC:1591
738087
Mouse
MGI:2142980
244886
Rat
RGD:1562084
501002
Dog
transmembrane protein 266 [Source:HGNC Symbol;Acc:HGNC:26763]
Horse
transmembrane protein 266
VGNC:24279
100060795
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 266
Mouse
Rat
Dog
transmembrane protein 266 [Source:HGNC Symbol;Acc:HGNC:26763]
Horse
transmembrane protein 266
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2M3C6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (14)
1 – 10 of 14
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.999834171
p_ni:  0.000165829
Score:  0.188
Data Source:  BioPlex,STRINGDB
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.999380288
p_ni:  0.000619712
Score:  0.795
Data Source:  BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.997269745
p_ni:  0.002730214
p_wrong:  4.1e-8
Score:  0.802
Data Source:  BioPlex,STRINGDB
STX5
Tbio
Novelty:  0.00964918
p_int:  0.992022722
p_ni:  0.007977278
Data Source:  BioPlex
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.911408334
p_ni:  0.088591664
p_wrong:  2e-9
Data Source:  BioPlex
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.89649482
p_ni:  0.103486123
p_wrong:  0.000019057
Score:  0.183
Data Source:  BioPlex,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
p_int:  0.888586962
p_ni:  0.111413023
p_wrong:  1.5e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
HM13
Tbio
Family:  Enzyme
Novelty:  0.0051333
p_int:  0.882619123
p_ni:  0.117380877
Score:  0.359
Data Source:  BioPlex,STRINGDB
KCMF1
Tbio
Family:  Enzyme
Novelty:  0.05485534
p_int:  0.872431835
p_ni:  0.127568161
p_wrong:  4e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
p_int:  0.778271764
p_ni:  0.221728236
Score:  0.188
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.64

PubMed score by year
PubTator Score  0.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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