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Tchem
AAK1
AP2-associated protein kinase 1

Protein Summary
Description
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts wit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406297
  • ENSP00000385181
  • ENSG00000115977
  • ENST00000409085
  • ENSP00000386456

Symbol
  • KIAA1048
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.98
kinase perturbation
0.97
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.34   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.34   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
1
2
75.6
hemoglobin measurement
2
1
2
59.8
hematocrit
2
1
2
51.9
dentures
2
1
2
30
dental caries
1
1
1
26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
75.6
hemoglobin measurement
2
59.8
hematocrit
2
51.9
dentures
2
30
dental caries
1
26
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Protein-Protein Interactions (150)
1 – 10 of 150
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.999999998
p_ni: 2e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
AP2S1
Tbio
Novelty: 0.01931502
p_int: 0.999999996
p_ni: 3e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
REPS1
Tbio
Novelty: 0.08952347
p_int: 0.999999846
p_ni: 1.54e-7
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
p_int: 0.999995587
p_ni: 0.000004412
p_wrong: 1e-9
Score: 0.88
Data Source: BioPlex,STRINGDB
DIEXF
Tbio
Novelty: 0.05892659
p_int: 0.999852794
p_ni: 0.000143843
p_wrong: 0.000003363
Data Source: BioPlex
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.999714425
p_ni: 0.000285575
Score: 0.95
Data Source: BioPlex,STRINGDB
AP2B1
Tbio
Novelty: 0.00921093
Score: 0.972
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.971
Data Source: STRINGDB
AP2A1
Tbio
Novelty: 0.08554974
Score: 0.965
Data Source: STRINGDB
CLTB
Tbio
Novelty: 0.00931222
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  46.34

PubMed score by year
PubTator Score  15.17

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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