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Tbio
ODF4
Outer dense fiber protein 4

Protein Summary
Description
Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton. This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328248
  • ENSP00000331086
  • ENSG00000184650

Symbol
  • OPPO1
  • CT134
  • CT136
  • OPPO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.65
tissue
0.62
tissue sample
0.44
cell line
0.41
cellular component
0.36


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.4   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.951035401
p_ni:  0.048964555
p_wrong:  4.4e-8
Data Source:  BioPlex
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.915345956
p_ni:  0.084654044
Data Source:  BioPlex
TMBIM6
Tbio
Novelty:  0.00151958
p_int:  0.901175304
p_ni:  0.098824685
p_wrong:  1.1e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
CLPTM1
Tbio
Novelty:  0.06426049
p_int:  0.812377259
p_ni:  0.187622741
Score:  0.282
Data Source:  BioPlex,STRINGDB
ODF3
Tbio
Novelty:  0.08747036
Score:  0.725
Data Source:  STRINGDB
FBXO39
Tbio
Novelty:  0.05342001
Score:  0.723
Data Source:  STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
Score:  0.71
Data Source:  STRINGDB
SPATA19
Tbio
Novelty:  0.06203122
Score:  0.687
Data Source:  STRINGDB
TSGA10
Tbio
Novelty:  0.04928862
Score:  0.687
Data Source:  STRINGDB
RGS22
Tbio
Novelty:  0.21787489
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
4
94.2
hemoglobin measurement
2
2
2
84.7
total cholesterol measurement
2
2
2
77.4
mean corpuscular volume
1
1
1
72.9
reticulocyte measurement
1
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
94.2
hemoglobin measurement
2
84.7
total cholesterol measurement
2
77.4
mean corpuscular volume
1
72.9
reticulocyte measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 4
VGNC:9490
747075
Macaque
outer dense fiber of sperm tails 4
717320
Mouse
MGI:2182079
252868
Rat
RGD:1359332
303236
Dog
outer dense fiber of sperm tails 4
VGNC:53430
479495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
outer dense fiber of sperm tails 4
Macaque
outer dense fiber of sperm tails 4
Mouse
Rat
Dog
outer dense fiber of sperm tails 4
Publication Statistics
PubMed Score 7.40
PubMed score by year
PubTator Score 5.34
PubTator score by year
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Related Publications
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PMID
Year
Title