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Tdark
CCDC27
Coiled-coil domain-containing protein 27

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
37.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
37.9
Protein-Protein Interactions (16)
1 – 10 of 16
CLTCL1
Tbio
Novelty: 0.05667807
p_int: 0.998393667
p_ni: 0.001606333
Score: 0.177
Data Source: BioPlex,STRINGDB
ALOXE3
Tbio
Family: Enzyme
Novelty: 0.02560954
p_int: 0.940825079
p_ni: 0.05891971
p_wrong: 0.000255211
Score: 0.189
Data Source: BioPlex,STRINGDB
HAL
Tbio
Family: Enzyme
Novelty: 0.01504631
p_int: 0.828316341
p_ni: 0.171683659
Score: 0.169
Data Source: BioPlex,STRINGDB
ALOX12B
Tbio
Family: Enzyme
Novelty: 0.02778552
p_int: 0.787378544
p_ni: 0.212621345
p_wrong: 1.12e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
WASF2
Tbio
Novelty: 0.00968798
p_int: 0.782654016
p_ni: 0.184348633
p_wrong: 0.032997351
Score: 0.188
Data Source: BioPlex,STRINGDB
C1orf174
Tdark
Novelty: 4.20172485
Score: 0.735
Data Source: STRINGDB
CEP104
Tbio
Novelty: 0.07564892
Score: 0.665
Data Source: STRINGDB
LRRC47
Tdark
Novelty: 0.73509239
Score: 0.665
Data Source: STRINGDB
ACTRT2
Tdark
Novelty: 0.38919779
Score: 0.577
Data Source: STRINGDB
WRAP73
Tbio
Novelty: 0.25394934
Score: 0.553
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.56

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer