Tbio ARHGAP31 Rho GTPase-activating protein 31

Protein Summary

Description

Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q2M1Z3
• Q9ULL6

Gene Name

• ARHGAP31

Ensembl ID

• ENST00000264245
• ENSP00000264245
• ENSG00000031081

Symbol

• CDGAP
• KIAA1204
• AOS1
• CDGAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.88
microRNA	0.8
drug perturbation	0.71
tissue sample	0.67
gene perturbation	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.46   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 30   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.46   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0