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Tbio
KIF7
Kinesin-like protein KIF7

Protein Summary
Description
Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms (PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation (By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development (By similarity). T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394412
  • ENSP00000377934
  • ENSG00000166813

Symbol
  • ACLS
  • AGBK
  • HLS2
  • JBTS12
  • UNQ340
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.66
phenotype
0.61
protein domain
0.58
tissue sample
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.45   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.45   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Hedgehog 'off' state (R-HSA-5610787)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hedgehog 'off' state
Reactome
Hedgehog 'on' state
Reactome
Signal Transduction
Reactome
Signaling by Hedgehog
Name
Explore in Pharos
Explore in Source
Hedgehog 'off' state
Hedgehog 'on' state
Signal Transduction
Signaling by Hedgehog
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (86)
1 – 10 of 86
ZNF785
Tdark
Family: TF
Novelty: 0.42629766
p_int: 0.999995924
p_ni: 0.000003795
p_wrong: 2.81e-7
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.999995604
p_ni: 0.000004395
p_wrong: 1e-9
Data Source: BioPlex
CINP
Tbio
Family: Enzyme
Novelty: 0.07004715
p_int: 0.999961911
p_ni: 0.000038077
p_wrong: 1.3e-8
Score: 0.189
Data Source: BioPlex,STRINGDB
ZNF331
Tbio
Family: TF
Novelty: 0.05976217
p_int: 0.999954335
p_ni: 0.000045664
Data Source: BioPlex
TNFAIP6
Tbio
Novelty: 0.0046811
p_int: 0.99991361
p_ni: 0.00008639
Data Source: BioPlex
FGL2
Tbio
Novelty: 0.01108434
p_int: 0.999864594
p_ni: 0.000135406
Score: 0.567
Data Source: BioPlex,STRINGDB
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.999687478
p_ni: 0.000312522
Data Source: BioPlex
NUP62
Tbio
Novelty: 0.01432724
p_int: 0.999674457
p_ni: 0.000325543
Data Source: BioPlex
LRRCC1
Tdark
Novelty: 0.14730953
p_int: 0.999220702
p_ni: 0.000779297
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ZNF74
Tbio
Family: TF
Novelty: 0.10554307
p_int: 0.999021435
p_ni: 0.000978563
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  33.45

PubMed score by year
PubTator Score  29.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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