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Tbio
KIF26B
Kinesin-like protein KIF26B

Protein Summary
Description
Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity). The protein encoded by this gene is an intracellular motor protein thought to transport organelles along microtubules. The encoded protein is required for kidney development. Elevated levels of this protein have been found in some breast and colorectal cancers. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407071
  • ENSP00000385545
  • ENSG00000162849
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
trait
0.97
transcription factor binding site profile
0.86
histone modification site profile
0.76
transcription factor
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.8   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.8   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
21.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 26B
VGNC:53257
457869
Mouse
MGI:2447076
269152
Rat
RGD:1560022
305012
Dog
kinesin family member 26B
VGNC:42400
490379
Horse
kinesin family member 26B
VGNC:19413
100059372
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 26B
Mouse
Rat
Dog
kinesin family member 26B
Horse
kinesin family member 26B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2KJY2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (126)
1 – 10 of 126
LIN7C
Tbio
Novelty:  0.06778878
p_int:  0.999999665
p_ni:  1.6e-8
p_wrong:  3.19e-7
Score:  0.295
Data Source:  BioPlex,STRINGDB
LIN7B
Tbio
Novelty:  0.12689192
p_int:  0.999907524
p_ni:  2.01e-7
p_wrong:  0.000092275
Data Source:  BioPlex
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.932
Data Source:  STRINGDB
KLC2
Tbio
Novelty:  0.06284367
Score:  0.93
Data Source:  STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
Score:  0.926
Data Source:  STRINGDB
KIF23
Tbio
Novelty:  0.00719651
Score:  0.925
Data Source:  STRINGDB
KIF27
Tbio
Novelty:  0.16575818
Score:  0.921
Data Source:  STRINGDB
KIFC2
Tbio
Novelty:  0.10989267
Score:  0.921
Data Source:  STRINGDB
RACGAP1
Tbio
Family:  Enzyme
Novelty:  0.01197099
Score:  0.919
Data Source:  STRINGDB
KLC3
Tbio
Novelty:  0.0528937
Score:  0.918
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.80

PubMed score by year
PubTator Score  11.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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