Tdark GSG1 Germ cell-specific gene 1 protein

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Germ Cell-specific Gene 1 Protein

DTO Classes

Protein / Cellular Structure / Germ Cell-specific Gene 1 Protein

Protein Summary

Description

May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum.

Uniprot Accession IDs

• Q2KHT4
• Q8N4M3
• Q8NBR4
• Q8NBS0
• Q8NBT1
• Q96LP9
• Q96SI6
• Q9BUY4

Gene Name

• GSG1

Ensembl ID

• ENST00000337630
• ENSP00000336816
• ENSG00000111305
• ENST00000396302
• ENSP00000379596
• ENST00000432710
• ENSP00000405032
• ENST00000457134
• ENSP00000398384
• ENST00000537302
• ENSP00000441718

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.7
transcription factor	0.62
cellular component	0.6
PubMedID	0.56
cell type or tissue	0.54

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.56   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	5	10		98
serum albumin measurement	EFO_0004535	1	1	1		24.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	10		98
serum albumin measurement	EFO_0004535	1		24.5

Reset Zoom  Beta Count   Odds Ratio

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	germ cell associated 1	VGNC:5408	465302
Macaque	germ cell associated 1		698194
Mouse	germ cell associated 1	MGI:1194499	14840
Rat	germ cell associated 1	RGD:1306546	312793
Dog	germ cell associated 1	VGNC:41528	486677

Species	Name	OMA	EggNOG	Inparanoid
Chimp	germ cell associated 1
Macaque	germ cell associated 1
Mouse	germ cell associated 1
Rat	germ cell associated 1
Dog	germ cell associated 1

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q2KHT4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)

Functions (1)

Components (3)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA polymerase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (19)

Explore Interacting Targets

1 – 10 of 19

• See Interactions on String-DB

IL37

Tbio

Novelty:  0.00499186

p_int:  0.892439433

p_ni:  0.107559301

p_wrong:  0.000001266

Score:  0.379

Data Source:  BioPlex,STRINGDB

ASAH1

Tchem

Family:  Enzyme

Novelty:  0.00374228

p_int:  0.858386254

p_ni:  0.141613087

p_wrong:  6.59e-7

Score:  0.241

Data Source:  BioPlex,STRINGDB

ATP4A

Tclin

Family:  Transporter

Novelty:  0.00008783

Score:  0.652

Data Source:  STRINGDB

ARFIP2

Tbio

Novelty:  0.01200959

Score:  0.536

Data Source:  STRINGDB

SHISA9

Tbio

Novelty:  0.10986428

Score:  0.536

Data Source:  STRINGDB

FHL5

Tbio

Novelty:  0.27618006

Score:  0.515

Data Source:  STRINGDB

NRN1

Tbio

Novelty:  0.01198116

Score:  0.514

Data Source:  STRINGDB

PPID

Tchem

Family:  Enzyme

Novelty:  0.01068886

Score:  0.493

Data Source:  STRINGDB

C10orf62

Tdark

Novelty:  12.75

Score:  0.488

Data Source:  STRINGDB

VWC2

Tdark

Novelty:  0.30211591

Score:  0.483

Data Source:  STRINGDB

Publication Statistics

PubMed Score  0.56

PubMed score by year

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PubTator Score  0.74

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Endoplasmic reticulum
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
heel bone mineral density
serum albumin measurement