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Tdark
RFX7
DNA-binding protein RFX7

Protein Summary
Description
RFX7 is a member of the regulatory factor X (RFX) family of transcription factors (see RFX1, MIM 600006) (Aftab et al., 2008 [PubMed 18673564]).[supplied by OMIM, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000559447
  • ENSP00000453281
  • ENSG00000181827

Symbol
  • RFXDC2
  • RFXDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.76
microRNA
0.75
transcription factor binding site profile
0.72
tissue
0.7
interacting protein
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
3
5
98
red blood cell density measurement
1
1
1
54.1
prostate carcinoma
1
1
0
1.2
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
98
red blood cell density measurement
1
54.1
prostate carcinoma
0
1.2
20.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
regulatory factor X7
698878
Mouse
MGI:2442675
319758
Rat
RGD:1308795
315804
Dog
regulatory factor X7
VGNC:45509
100855421
Horse
regulatory factor X7
VGNC:22331
100054682
Species
Name
OMA
EggNOG
Inparanoid
Macaque
regulatory factor X7
Mouse
Rat
Dog
regulatory factor X7
Horse
regulatory factor X7
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q2KHR2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (45)
1 – 10 of 45
RFX5
Tbio
Family: TF
Novelty: 0.02002111
p_int: 1
Score: 0.779
Data Source: BioPlex,STRINGDB
RFXANK
Tbio
Novelty: 0.00355465
Score: 0.989
Data Source: STRINGDB
ANKRA2
Tbio
Novelty: 0.19358401
Score: 0.976
Data Source: STRINGDB
TTC25
Tdark
Novelty: 0.23064129
Score: 0.83
Data Source: STRINGDB
RFXAP
Tbio
Novelty: 0.04422686
Score: 0.699
Data Source: STRINGDB
DTX2
Tbio
Family: Enzyme
Novelty: 0.01981892
Score: 0.696
Data Source: STRINGDB
SS18L1
Tbio
Novelty: 0.10255799
Score: 0.693
Data Source: STRINGDB
CCNK
Tbio
Novelty: 0.03528971
Score: 0.681
Data Source: STRINGDB
DTX1
Tbio
Family: Enzyme
Novelty: 0.00972217
Score: 0.664
Data Source: STRINGDB
CIITA
Tbio
Novelty: 0.00245662
Score: 0.572
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.97

PubMed score by year
PubTator Score  2.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer