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Tbio
RSPO4
R-spondin-4

Protein Summary
Description
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076). This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217260
  • ENSP00000217260
  • ENSG00000101282
  • ENST00000400634
  • ENSP00000383475

Symbol
  • C20orf182
  • CRISTIN4
  • C20orf182
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
transcription factor
0.59
cell type or tissue
0.56
tissue sample
0.56
gene perturbation
0.53


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.44   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
R-spondin 4
VGNC:14290
469857
Macaque
R-spondin 4
715268
Mouse
MGI:1924467
228770
Rat
RGD:1563415
499918
Dog
R-spondin 4
VGNC:45784
485813
Species
Name
OMA
EggNOG
Inparanoid
Chimp
R-spondin 4
Macaque
R-spondin 4
Mouse
Rat
Dog
R-spondin 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2I0M5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (26)
1 – 10 of 26
LGR4
Tbio
Family: GPCR
Novelty: 0.01180123
Score: 0.988
Data Source: Reactome,STRINGDB
ZNRF3
Tbio
Family: Enzyme
Novelty: 0.03351825
Score: 0.982
Data Source: Reactome,STRINGDB
LGR6
Tbio
Family: GPCR
Novelty: 0.02186397
Score: 0.968
Data Source: Reactome,STRINGDB
RNF43
Tbio
Family: Enzyme
Novelty: 0.01258908
Score: 0.967
Data Source: Reactome,STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.961
Data Source: Reactome,STRINGDB
RSPO1
Tbio
Novelty: 0.00365075
Score: 0.911
Data Source: STRINGDB
RSPO3
Tbio
Novelty: 0.02321039
Score: 0.909
Data Source: STRINGDB
RSPO2
Tbio
Novelty: 0.0188211
Score: 0.907
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.902
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.44

PubMed score by year
PubTator Score  15.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer