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Tbio
LRRC26
Leucine-rich repeat-containing protein 26

Protein Classes
Protein Summary
Description
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371542
  • ENSP00000360597
  • ENSG00000184709

Symbol
  • CAPC
  • CAPC
  • bA350O14.10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
cell type or tissue
0.63
protein domain
0.58
tissue
0.46
transcription factor
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
89.1
creatinine measurement
1
2
2
86.1
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
serum urea measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
creatinine measurement
2
86.1
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
serum urea measurement
1
54.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 26
VGNC:8904
465175
Mouse
MGI:2385129
227618
Rat
RGD:1308398
311803
Dog
leucine rich repeat containing 26
VGNC:42792
606959
Horse
leucine rich repeat containing 26
VGNC:19773
100059826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 26
Mouse
Rat
Dog
leucine rich repeat containing 26
Horse
leucine rich repeat containing 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q2I0M4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (14)
1 – 10 of 14
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.825
Data Source:  STRINGDB
LRRC10
Tdark
Novelty:  0.1402206
Score:  0.743
Data Source:  STRINGDB
KCNMB1
Tbio
Family:  IC
Novelty:  0.00736653
Score:  0.718
Data Source:  STRINGDB
KRT1
Tbio
Novelty:  0.00278467
Score:  0.715
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.712
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.61
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.497
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.80

PubMed score by year
PubTator Score  22.87

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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