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Tbio
MICB
MHC class I polypeptide-related sequence B

Protein Summary
Description
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
trait
0.97
protein domain
0.85
biological term
0.8
disease
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.58   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.58   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
ANKRD2
Tbio
Novelty:  0.02153668
p_int:  0.99994712
p_ni:  0.00005288
Data Source:  BioPlex
MICA
Tbio
Novelty:  0.03965901
p_int:  0.999909675
p_ni:  0.000090322
p_wrong:  3e-9
Score:  0.807
Data Source:  BioPlex,STRINGDB
PLD6
Tbio
Family:  Enzyme
Novelty:  0.02802141
p_int:  0.999232496
p_ni:  0.000742327
p_wrong:  0.000025176
Data Source:  BioPlex
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.999206102
p_ni:  0.000793879
p_wrong:  2e-8
Data Source:  BioPlex
ARL17A
Tdark
Family:  Enzyme
Novelty:  0.37276049
p_int:  0.998834228
p_ni:  0.001065468
p_wrong:  0.000100304
Data Source:  BioPlex
GJA1
Tbio
Novelty:  0.00021332
p_int:  0.998417022
p_ni:  0.001582978
Data Source:  BioPlex
APOE
Tbio
Novelty:  0.00005049
p_int:  0.997458161
p_ni:  0.001745193
p_wrong:  0.000796646
Data Source:  BioPlex
NR2F2
Tchem
Family:  NR
Novelty:  0.00450561
p_int:  0.997383506
p_ni:  0.002616493
Data Source:  BioPlex
DNAH14
Tbio
Novelty:  0.28289652
p_int:  0.997190631
p_ni:  0.002674302
p_wrong:  0.000135067
Data Source:  BioPlex
OCLN
Tbio
Novelty:  0.00047671
p_int:  0.995182593
p_ni:  0.004817405
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (584)
Items per page:
1 – 5 of 584
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
9
0
2.3
98.5
1
9
0
2.3
98.5
1
9
0
2.3
98.5
1
9
0
2.3
98.5
HIV-1 infection
3
3
0
4.4
97.5
Items per page:
1 – 5 of 584
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.3
98.5
0
2.3
98.5
0
2.3
98.5
0
2.3
98.5
HIV-1 infection
0
4.4
97.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 397.58
PubMed score by year
PubTator Score 165.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title