You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HLA-DRB1
HLA class II histocompatibility antigen, DRB1-16 beta chain

Protein Summary
Description
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loa ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4163.15   (req: < 5)
Gene RIFs: 1105   (req: <= 3)
Antibodies: 952   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4163.15   (req: >= 5)
Gene RIFs: 1105   (req: > 3)
Antibodies: 952   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (786)
Items per page:
1 – 5 of 786
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
2
99.5
5
3
0
2
99.5
5
3
0
2
99.5
5
3
0
2
99.5
5
3
0
2
99.5
Items per page:
1 – 5 of 786
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2
99.5
0
2
99.5
0
2
99.5
0
2
99.5
0
2
99.5
Pathways (91)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Cytokine Signaling in Immune system
Downstream TCR signaling
Generation of second messenger molecules
Gene Ontology Terms (30)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (388)
1 – 10 of 388
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.999
Data Source: STRINGDB
CD74
Tchem
Novelty: 0.00281228
Score: 0.998
Data Source: STRINGDB
HLA-DMA
Tbio
Novelty: 0.00405566
Score: 0.997
Data Source: STRINGDB
CD4
Tclin
Novelty: 0.00001217
Score: 0.986
Data Source: STRINGDB
HLA-DRB5
Tbio
Novelty: 0.00291303
Score: 0.98
Data Source: STRINGDB
PTPN22
Tchem
Family: Enzyme
Novelty: 0.00168847
Score: 0.98
Data Source: STRINGDB
HLA-DMB
Tbio
Novelty: 0.02289537
Score: 0.979
Data Source: STRINGDB
HLA-DPA1
Tbio
Novelty: 0.01080446
Score: 0.975
Data Source: STRINGDB
HLA-DQA1
Tbio
Novelty: 0.00077488
Score: 0.964
Data Source: STRINGDB
HLA-DQA2
Tbio
Novelty: 0.00431613
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  4163.15

PubMed score by year
PubTator Score  4503.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: