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Tbio
HLA-C
HLA class I histocompatibility antigen, Cw-18 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420206
  • ENSP00000410214
  • ENSG00000228299

Symbol
  • HLAC
  • MHC
  • HLAC
  • HLC-C
  • D6S204
  • PSORS1
  • HLA-JY3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1493.61   (req: < 5)
View Publications
Gene RIFs: 304   (req: <= 3)
View Gene RIFs
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1493.61   (req: >= 5)
Gene RIFs: 304   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (165)
Items per page:
1 – 5 of 165
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
EFO_0004343
ENSG00000206435
2
1
10
94.1
waist-hip ratio
EFO_0004343
ENSG00000206452
2
1
10
94.1
waist-hip ratio
EFO_0004343
ENSG00000237022
2
1
6
94.1
waist-hip ratio
EFO_0004343
ENSG00000206435
2
1
10
94.1
waist-hip ratio
EFO_0004343
ENSG00000206435
2
1
10
94.1
Items per page:
1 – 5 of 165
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
EFO_0004343
10
94.1
waist-hip ratio
EFO_0004343
10
94.1
waist-hip ratio
EFO_0004343
6
94.1
waist-hip ratio
EFO_0004343
10
94.1
waist-hip ratio
EFO_0004343
10
94.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
471962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
Pathways (40)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
894 targets
R-HSA-1280218
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
92 targets
R-HSA-983170
Reactome
Antigen processing-Cross presentation
169 targets
R-HSA-1236975
Reactome
Class I MHC mediated antigen processing & presentation
437 targets
R-HSA-983169
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
894 targets
R-HSA-1280218
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
92 targets
R-HSA-983170
Antigen processing-Cross presentation
169 targets
R-HSA-1236975
Class I MHC mediated antigen processing & presentation
437 targets
R-HSA-983169
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
peptide antigen binding
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (290)
1 – 10 of 290
B2M
Tbio
Novelty: 0.00011248
Score: 0.999
Data Source: STRINGDB
KIR2DL3
Tbio
Novelty: 0.00599644
Score: 0.995
Data Source: STRINGDB
KIR2DL1
Tbio
Novelty: 0.00523657
Score: 0.994
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00270731
Score: 0.984
Data Source: STRINGDB
Publication Statistics
PubMed Score  1493.61

PubMed score by year
PubTator Score  2752.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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