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Tbio
INSC
Protein inscuteable homolog

Protein Summary
Description
May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379554
  • ENSP00000368872
  • ENSG00000188487
  • ENST00000379556
  • ENSP00000368874
  • ENST00000525218
  • ENSP00000436113
  • ENST00000528567
  • ENSP00000435022
  • ENST00000530161
  • ENSP00000436194
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
gene perturbation
0.71
disease
0.68
phenotype
0.67
transcription factor
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
PARD3B
Tbio
Novelty:  0.09155541
Score:  0.984
Data Source:  STRINGDB
GPSM2
Tbio
Novelty:  0.00941766
Score:  0.975
Data Source:  STRINGDB
PARD3
Tbio
Novelty:  0.00521327
Score:  0.964
Data Source:  STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
Score:  0.962
Data Source:  STRINGDB
NUMB
Tbio
Novelty:  0.00211228
Score:  0.888
Data Source:  STRINGDB
NUMBL
Tbio
Novelty:  0.01383607
Score:  0.835
Data Source:  STRINGDB
PCP2
Tdark
Novelty:  0.05083955
Score:  0.755
Data Source:  STRINGDB
TTC28
Tdark
Novelty:  0.16651519
Score:  0.755
Data Source:  STRINGDB
WHRN
Tbio
Novelty:  0.01886351
Score:  0.675
Data Source:  STRINGDB
PDE3B
Tclin
Family:  Enzyme
Novelty:  0.0088954
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
4
8
11
99.2
heel bone mineral density
4
3
8
96.9
information processing speed
1
1
1
41.5
bowel opening frequency
1
1
1
40.6
migraine disorder
1
1
0
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
11
99.2
heel bone mineral density
8
96.9
information processing speed
1
41.5
bowel opening frequency
1
40.6
migraine disorder
0
1
11.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inscuteable homolog
VGNC:3250
748649
Macaque
INSC, spindle orientation adaptor protein
698076
Mouse
MGI:1917942
233752
Rat
RGD:1311379
293166
Dog
INSC, spindle orientation adaptor protein
VGNC:42038
611775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inscuteable homolog
Macaque
INSC, spindle orientation adaptor protein
Mouse
Rat
Dog
INSC, spindle orientation adaptor protein
Publication Statistics
PubMed Score 60.17
PubMed score by year
PubTator Score 70.18
PubTator score by year
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Related Publications
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PMID
Year
Title