Tbio DUOXA1 Dual oxidase maturation factor 1

Protein Summary

Description

May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q1HG43
• Q8N6K9
• Q96MI4

Gene Name

• DUOXA1

Ensembl ID

• ENST00000267803
• ENSP00000267803
• ENSG00000140254
• ENST00000558422
• ENSP00000453836
• ENST00000558996
• ENSP00000454019
• ENST00000559014
• ENSP00000453569
• ENST00000560572
• ENSP00000454084

Symbol

• NIP
• NUMBIP
• NIP
• mol
• NUMBIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.79
cell type or tissue	0.77
tissue	0.55
PubMedID	0.46
biological process	0.44

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.99   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.99   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0