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Tdark
SLC5A12
Sodium-coupled monocarboxylate transporter 2

Protein Classes
Protein Summary
Description
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity). Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity). Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280467
  • ENSP00000280467
  • ENSG00000148942
  • ENST00000396005
  • ENSP00000379326

Symbol
  • SMCT2
  • SMCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
microRNA
0.67
tissue
0.63
cell type or tissue
0.57
disease perturbation
0.56


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.37   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 13   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.37   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 13   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 12
VGNC:11654
451085
Macaque
solute carrier family 5 member 12
702217
Mouse
MGI:2138890
241612
Rat
RGD:1311652
362188
Dog
solute carrier family 5 member 12
VGNC:46445
476893
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 5 member 12
Macaque
solute carrier family 5 member 12
Mouse
Rat
Dog
solute carrier family 5 member 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q1EHB4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Multifunctional anion exchangers (R-HSA-427601)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Multifunctional anion exchangers
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Multifunctional anion exchangers
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (39)
1 – 10 of 39
TAX1BP1
Tbio
Novelty: 0.02498501
p_int: 0.780480762
p_ni: 0.219519236
p_wrong: 3e-9
Score: 0.403
Data Source: BioPlex,STRINGDB
SLC22A12
Tclin
Family: Transporter
Novelty: 0.00318081
Score: 0.91
Data Source: STRINGDB
SLC13A3
Tbio
Family: Transporter
Novelty: 0.02627177
Score: 0.824
Data Source: STRINGDB
SLC13A4
Tbio
Family: Transporter
Novelty: 0.01859297
Score: 0.77
Data Source: STRINGDB
CEBPD
Tbio
Family: TF
Novelty: 0.00121121
Score: 0.755
Data Source: STRINGDB
SLC16A8
Tbio
Family: Transporter
Novelty: 0.03197385
Score: 0.725
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.708
Data Source: STRINGDB
SLC25A47
Tbio
Family: Transporter
Novelty: 0.57588107
Score: 0.691
Data Source: STRINGDB
SLC13A1
Tbio
Family: Transporter
Novelty: 0.01582826
Score: 0.629
Data Source: STRINGDB
EMB
Tbio
Novelty: 0.00135577
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.37

PubMed score by year
PubTator Score  4.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer