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Tdark
LONRF1
LON peptidase N-terminal domain and RING finger protein 1

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.82   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
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GENEVA
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ARCHS4
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Protein-Protein Interactions (274)
1 – 10 of 274
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
p_int:  0.999769969
p_ni:  0.000230031
Score:  0.211
Data Source:  BioPlex,STRINGDB
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.858667283
p_ni:  0.141332717
Score:  0.187
Data Source:  BioPlex,STRINGDB
KCNJ5
Tchem
Family:  IC
Novelty:  0.00385775
p_int:  0.847070351
p_ni:  0.142393394
p_wrong:  0.010536255
Score:  0.248
Data Source:  BioPlex,STRINGDB
ISCU
Tbio
Novelty:  0.0043097
p_int:  0.778474948
p_ni:  0.000014269
p_wrong:  0.221510782
Score:  0.544
Data Source:  BioPlex,STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.97
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.959
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.943
Data Source:  STRINGDB
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
Score:  0.924
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.924
Data Source:  STRINGDB
TRIM36
Tbio
Family:  Enzyme
Novelty:  0.06724803
Score:  0.923
Data Source:  STRINGDB
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
59.5
mathematical ability
2
1
2
56.4
self reported educational attainment
2
2
2
51.4
smoking status measurement
1
1
1
35
diet measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
59.5
mathematical ability
2
56.4
self reported educational attainment
2
51.4
smoking status measurement
1
35
diet measurement
1
26.1
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 1
VGNC:855
464000
Macaque
LON peptidase N-terminal domain and ring finger 1
706469
Mouse
MGI:3609241
244421
Rat
RGD:1562583
306505
Dog
LON peptidase N-terminal domain and ring finger 1
VGNC:42734
482886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LON peptidase N-terminal domain and ring finger 1
Macaque
LON peptidase N-terminal domain and ring finger 1
Mouse
Rat
Dog
LON peptidase N-terminal domain and ring finger 1
Publication Statistics
PubMed Score 1.82
PubMed score by year