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Tbio
ARHGAP44
Rho GTPase-activating protein 44

Protein Summary
Description
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340825
  • ENSP00000342566
  • ENSG00000006740
  • ENST00000379672
  • ENSP00000368994

Symbol
  • KIAA0672
  • RICH2
  • RICH2
  • NPC-A-10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
tissue
0.62
phenotype
0.59
protein domain
0.58
transcription factor
0.57


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 44
VGNC:6342
455062
Macaque
Rho GTPase activating protein 44
718174
Mouse
MGI:2144423
216831
Rat
RGD:1305664
303222
Dog
Rho GTPase activating protein 44
VGNC:38065
489510
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rho GTPase activating protein 44
Macaque
Rho GTPase activating protein 44
Mouse
Rat
Dog
Rho GTPase activating protein 44
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q17R89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (60)
1 – 10 of 60
ARHGAP17
Tbio
Family: Enzyme
Novelty: 0.06611987
p_int: 1
Score: 0.834
Data Source: BioPlex,STRINGDB
FNBP1L
Tbio
Novelty: 0.01235857
p_int: 0.99999999
p_ni: 7e-9
p_wrong: 3e-9
Score: 0.514
Data Source: BioPlex,STRINGDB
SH3BP1
Tbio
Novelty: 8.50014339
p_int: 0.99999845
p_ni: 0.00000155
Score: 0.873
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999991321
p_ni: 0.000008679
Score: 0.216
Data Source: BioPlex,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.999975476
p_ni: 0.000024506
p_wrong: 1.9e-8
Score: 0.813
Data Source: BioPlex,STRINGDB
TRIP10
Tbio
Novelty: 0.01553463
p_int: 0.999866369
p_ni: 0.000133631
Score: 0.579
Data Source: BioPlex,STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
p_int: 0.998904
p_ni: 0.001096
Score: 0.595
Data Source: BioPlex,STRINGDB
CASP5
Tchem
Family: Enzyme
Novelty: 0.00734661
p_int: 0.992134868
p_ni: 0.000478228
p_wrong: 0.007386904
Score: 0.345
Data Source: BioPlex,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.974293954
p_ni: 0.024816429
p_wrong: 0.000889617
Data Source: BioPlex
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.899146535
p_ni: 0.100853465
Score: 0.171
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.02

PubMed score by year
PubTator Score  8.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer