You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TXNRD1
Thioredoxin reductase 1, cytoplasmic

Protein Summary
Description
Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid. The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000503506
  • ENSP00000421934
  • ENSG00000198431
  • ENST00000524698
  • ENSP00000433425
  • ENST00000525566
  • ENSP00000434516
  • ENST00000526390
  • ENSP00000435123
  • ENST00000526691
  • ENSP00000435929
  • ENST00000529546
  • ENSP00000434919

Symbol
  • GRIM12
  • KDRF
  • TR
  • TR1
  • TXNR
  • TRXR1
  • GRIM-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.97
chemical
0.93
kinase perturbation
0.91
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.17   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.17   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1