Tbio CDO1 Cysteine dioxygenase type 1

Protein Summary

Description

Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Uniprot Accession IDs

• Q16878
• B2RAK4
• P78513
• Q6FHZ8
• Q8TB64

Gene Name

• CDO1

Ensembl ID

• ENST00000250535
• ENSP00000250535
• ENSG00000129596

Symbol

• CDO-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.76
disease perturbation	0.74
PubMedID	0.69
biological process	0.68
histone modification site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.04   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.04   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0