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Tchem
PFKFB4
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

Protein Summary
Description
Synthesis and degradation of fructose 2,6-bisphosphate. The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000232375
  • ENSP00000232375
  • ENSG00000114268
  • ENST00000383734
  • ENSP00000373240
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.85
histone modification site profile
0.66
kinase perturbation
0.6
transcription factor binding site profile
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.09   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.09   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (33)
Glucose metabolism (R-HSA-70326)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Reactome
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Name
Explore in Pharos
Explore in Source
Glucose metabolism
Glycolysis
Metabolism
Metabolism of carbohydrates
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
Protein-Protein Interactions (62)
1 – 10 of 62
PFKFB3
Tchem
Family: Kinase
Novelty: 0.00432172
p_int: 1
Score: 0.968
Data Source: BioPlex,STRINGDB
TIGAR
Tbio
Family: Enzyme
Novelty: 0.01383639
Score: 0.993
Data Source: STRINGDB
PFKFB1
Tbio
Family: Kinase
Novelty: 0.05463358
Score: 0.918
Data Source: STRINGDB
MPI
Tchem
Family: Enzyme
Novelty: 0.00966817
Score: 0.916
Data Source: STRINGDB
PFKFB2
Tchem
Family: Kinase
Novelty: 0.02120834
Score: 0.903
Data Source: STRINGDB
PFKM
Tbio
Family: Kinase
Novelty: 0.00334458
Score: 0.902
Data Source: STRINGDB
PFKP
Tbio
Family: Kinase
Novelty: 0.0112356
Score: 0.856
Data Source: STRINGDB
PFKL
Tbio
Family: Kinase
Novelty: 0.00824192
Score: 0.833
Data Source: STRINGDB
HK2
Tchem
Family: Kinase
Novelty: 0.00222818
Score: 0.824
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00089993
Score: 0.792
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.09

PubMed score by year
PubTator Score  24.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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