Tchem PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

Protein Summary

Description

Synthesis and degradation of fructose 2,6-bisphosphate. The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• Q16875
• B7Z955
• O43622
• O75902
• Q5VX15
• Q5VX18
• Q5VX19
• 6PF-2-K/Fru-2,6-P2ase 3

Gene Name

• PFKFB3

Ensembl ID

• ENST00000360521
• ENSP00000353712
• ENSG00000170525
• ENST00000379775
• ENSP00000369100
• ENST00000379789
• ENSP00000369115
• ENST00000536985
• ENSP00000443319

Symbol

• PFK2
• IPFK2
• iPFK-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
kinase perturbation	0.91
protein domain	0.85
transcription factor	0.84
virus perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Carbohydrate Phosphatase / 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

DTO Classes

Protein / Kinase / Non-protein Kinase / Carbohydrate Kinase / 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.26   (req: < 5)

Gene RIFs: 120   (req: <= 3)

Antibodies: 290   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 417.26   (req: >= 5)

Gene RIFs: 120   (req: > 3)

Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0