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Tchem
LTC4S
Leukotriene C4 synthase

Protein Classes
Protein Summary
Description
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292596
  • ENSP00000292596
  • ENSG00000213316
  • ENST00000639087
  • ENSP00000492334
  • ENSG00000283887
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.79
PubMedID
0.7
molecular function
0.67
cellular component
0.64
disease
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.25   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.25   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 106
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leukotriene C4 synthase
VGNC:13542
739986
Mouse
MGI:107498
17001
Rat
RGD:620677
114097
Dog
leukotriene C4 synthase
VGNC:51742
607316
Horse
leukotriene C4 synthase [Source:HGNC Symbol;Acc:HGNC:6719]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leukotriene C4 synthase
Mouse
Rat
Dog
leukotriene C4 synthase
Horse
leukotriene C4 synthase [Source:HGNC Symbol;Acc:HGNC:6719]
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16873-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DHA-derived sulfido conjugates
Reactome
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Reactome
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of DHA-derived SPMs
Biosynthesis of DHA-derived sulfido conjugates
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
Score: 0.988
Data Source: Reactome,STRINGDB
LTA4H
Tchem
Family: Enzyme
Novelty: 0.00505614
Score: 0.98
Data Source: STRINGDB
ALOX5AP
Tchem
Family: Enzyme
Novelty: 0.00165143
Score: 0.947
Data Source: Reactome,STRINGDB
GGT5
Tbio
Family: Enzyme
Novelty: 0.00602505
Score: 0.921
Data Source: STRINGDB
GGT1
Tbio
Family: Enzyme
Novelty: 0.00252374
Score: 0.904
Data Source: STRINGDB
MGST1
Tbio
Family: Enzyme
Novelty: 0.00681882
Score: 0.846
Data Source: STRINGDB
CYSLTR1
Tclin
Family: GPCR
Novelty: 0.00337777
Score: 0.81
Data Source: STRINGDB
CYSLTR2
Tchem
Family: GPCR
Novelty: 0.00895224
Score: 0.802
Data Source: STRINGDB
MGST3
Tbio
Family: Enzyme
Novelty: 0.02891864
Score: 0.761
Data Source: STRINGDB
FFAR3
Tchem
Family: GPCR
Novelty: 0.00746169
Score: 0.73
Data Source: STRINGDB
Publication Statistics
PubMed Score  107.25

PubMed score by year
PubTator Score  197.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer