Tbio DGUOK Deoxyguanosine kinase, mitochondrial

Protein Summary

Description

Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16854
• P78532
• Q16759
• Q4ZG09
• Q7L1W9
• Q96BC1
• dGK

Gene Name

• DGUOK

Ensembl ID

• ENST00000264093
• ENSP00000264093
• ENSG00000114956
• ENST00000348222
• ENSP00000306964
• ENST00000418996
• ENSP00000408209
• ENST00000629438
• ENSP00000487122

Symbol

• DGK
• dGK
• NCPH
• PEOB4
• MTDPS3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
molecular function	0.91
transcription factor perturbation	0.84
transcription factor binding site profile	0.82
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Deoxyguanosine Kinase, Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleoside Kinase / Dck/dgk Family / Deoxyguanosine Kinase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.23   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.23   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0