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Tchem
AOC3
Membrane primary amine oxidase

Protein Summary
Description
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308423
  • ENSP00000312326
  • ENSG00000131471
  • ENST00000591562
  • ENSP00000468632
  • ENST00000613571
  • ENSP00000484312
  • ENST00000617500
  • ENSP00000477686

Symbol
  • VAP1
  • HPAO
  • SSAO
  • VAP1
  • VAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
PubMedID
0.86
protein domain
0.85
biological term
0.72
gene perturbation
0.6


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.63   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1066.63   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 138
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
phenelzine
chemical structure image
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 3
VGNC:6339
454702
Macaque
amine oxidase, copper containing 3
711820
Mouse
MGI:1306797
11754
Dog
amine oxidase, copper containing 3
VGNC:37949
480511
Horse
membrane primary amine oxidase
100065767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
amine oxidase, copper containing 3
Macaque
amine oxidase, copper containing 3
Mouse
Dog
amine oxidase, copper containing 3
Horse
membrane primary amine oxidase
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16853-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Phase I - Functionalization of compounds
Gene Ontology Terms (24)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (63)
1 – 10 of 63
AOC2
Tchem
Family: Enzyme
Novelty: 0.0048282
p_int: 0.99999999
p_wrong: 9e-9
Score: 0.867
Data Source: BioPlex,STRINGDB
EXTL2
Tbio
Family: Enzyme
Novelty: 0.05051027
p_int: 0.999303611
p_ni: 0.000672676
p_wrong: 0.000023714
Score: 0.189
Data Source: BioPlex,STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
p_int: 0.998846028
p_ni: 0.001153964
p_wrong: 9e-9
Score: 0.216
Data Source: BioPlex,STRINGDB
MANEA
Tbio
Family: Enzyme
Novelty: 0.03693244
p_int: 0.997717642
p_ni: 0.002282354
p_wrong: 4e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
ERF
Tbio
Family: TF
Novelty: 0.00182385
p_int: 0.944216636
p_ni: 0.052400512
p_wrong: 0.003382852
Score: 0.215
Data Source: BioPlex,STRINGDB
ARL6IP6
Tdark
Novelty: 0.36643453
p_int: 0.8492064
p_ni: 0.150793596
p_wrong: 3e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.943
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.943
Data Source: STRINGDB
ALDH2
Tclin
Family: Enzyme
Novelty: 0.00077122
Score: 0.942
Data Source: STRINGDB
SMOX
Tbio
Family: Enzyme
Novelty: 0.0071711
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  1066.63

PubMed score by year
PubTator Score  184.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer