Tchem AOC3 Membrane primary amine oxidase

Protein Summary

Description

Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• Q16853
• B2RCI5
• K7ESB3
• L0L8N9
• Q45F94

Gene Name

• AOC3

Ensembl ID

• ENST00000308423
• ENSP00000312326
• ENSG00000131471
• ENST00000591562
• ENSP00000468632
• ENST00000613571
• ENSP00000484312
• ENST00000617500
• ENSP00000477686

Symbol

• VAP1
• HPAO
• SSAO
• VAP1
• VAP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.97
PubMedID	0.86
protein domain	0.85
biological term	0.72
gene perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1200.69   (req: < 5)

Gene RIFs: 83   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1200.69   (req: >= 5)

Gene RIFs: 83   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 168

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1