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Tbio
UGP2
UTP--glucose-1-phosphate uridylyltransferase

Protein Summary
Description
Plays a central role as a glucosyl donor in cellular metabolic pathways. The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337130
  • ENSP00000338703
  • ENSG00000169764
  • ENST00000394417
  • ENSP00000377939
  • ENST00000467648
  • ENSP00000420793

Symbol
  • UGP1
  • UDPG
  • UGP1
  • UDPGP
  • UGPP1
  • UGPP2
  • UDPGP2
  • pHC379
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.91
molecular function
0.86
kinase perturbation
0.81
pathway
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
6.6
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose pyrophosphorylase 2
VGNC:48976
459273
Macaque
UDP-glucose pyrophosphorylase 2
695178
Mouse
MGI:2183447
216558
Rat
RGD:1310210
289827
Dog
UDP-glucose pyrophosphorylase 2
VGNC:48120
474615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose pyrophosphorylase 2
Macaque
UDP-glucose pyrophosphorylase 2
Mouse
Rat
Dog
UDP-glucose pyrophosphorylase 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Formation of the active cofactor, UDP-glucuronate
Reactome
Glucuronidation
Reactome
Glycogen metabolism
Reactome
Glycogen synthesis
Name
Explore in Pharos
Explore in Source
Biological oxidations
Formation of the active cofactor, UDP-glucuronate
Glucuronidation
Glycogen metabolism
Glycogen synthesis
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (138)
1 – 10 of 138
GPSM1
Tbio
Novelty: 0.03510582
p_int: 0.999999612
p_ni: 3.88e-7
Score: 0.239
Data Source: BioPlex,STRINGDB
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.999997805
p_ni: 0.000002195
Score: 0.247
Data Source: BioPlex,STRINGDB
HDAC7
Tclin
Family: Epigenetic
Novelty: 0.00600484
p_int: 0.998080603
p_ni: 0.001919397
Score: 0.21
Data Source: BioPlex,STRINGDB
SUN2
Tbio
Novelty: 0.01387591
p_int: 0.978735941
p_ni: 0.021264054
p_wrong: 5e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
DCAF15
Tdark
Novelty: 0.13476661
p_int: 0.978333423
p_ni: 0.021666565
p_wrong: 1.3e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.92966985
p_ni: 0.07033014
p_wrong: 1.1e-8
Data Source: BioPlex
ZNHIT2
Tbio
Novelty: 0.13370912
p_int: 0.827349605
p_ni: 0.172095461
p_wrong: 0.000554935
Data Source: BioPlex
LONP2
Tbio
Family: Enzyme
Novelty: 0.04499043
p_int: 0.768194895
p_ni: 0.231805105
Data Source: BioPlex
GALE
Tchem
Family: Enzyme
Novelty: 0.00256798
Score: 0.989
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.988
Data Source: STRINGDB
Publication Statistics
PubMed Score  129.25

PubMed score by year
PubTator Score  84.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer