You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CYP51A1
Lanosterol 14-alpha demethylase

Protein Summary
Description
Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000450723
  • ENSP00000406757
  • ENSG00000001630

Symbol
  • CYP51
  • LDM
  • CP51
  • CYP51
  • CYPL1
  • P450L1
  • P450-14DM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
disease perturbation
0.93
transcription factor perturbation
0.91
transcription factor binding site profile
0.85
histone modification site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 839.78   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 839.78   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
longevity
1
1
0
5.4
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
longevity
0
5.4
35.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 51 subfamily A member 1
VGNC:7373
463527
Mouse
MGI:106040
13121
Rat
RGD:2481
25427
Dog
cytochrome P450 family 51 subfamily A member 1
VGNC:50376
475225
Horse
lanosterol 14-alpha demethylase
100050921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 51 subfamily A member 1
Mouse
Rat
Dog
cytochrome P450 family 51 subfamily A member 1
Horse
lanosterol 14-alpha demethylase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16850-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (47)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Biological oxidations
Reactome
Cholesterol biosynthesis
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Endogenous sterols
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Biological oxidations
Cholesterol biosynthesis
Cytochrome P450 - arranged by substrate type
Endogenous sterols
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (114)
1 – 10 of 114
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.999963922
p_ni: 0.000036076
p_wrong: 1e-9
Score: 0.233
Data Source: BioPlex,STRINGDB
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.989245752
p_ni: 0.010754248
Data Source: BioPlex
PTCHD3
Tbio
Novelty: 0.00081643
p_int: 0.984177737
p_ni: 0.015822263
Data Source: BioPlex
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
p_int: 0.934790712
p_ni: 0.065209288
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.929006428
p_ni: 0.070993572
Data Source: BioPlex
EVA1B
Tdark
Novelty: 2.1380272
p_int: 0.92422269
p_ni: 0.07577731
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.906764812
p_ni: 0.093235188
Data Source: BioPlex
PCDHA3
Tdark
Novelty: 0.8622898
p_int: 0.893359274
p_ni: 0.106640726
Data Source: BioPlex
OR10S1
Tdark
Family: oGPCR
Novelty: 2.23425255
p_int: 0.878935735
p_ni: 0.121064265
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.85539408
p_ni: 0.14460592
Data Source: BioPlex
Publication Statistics
PubMed Score  839.78

PubMed score by year
PubTator Score  226.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: