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Tbio
PTPRN
Receptor-type tyrosine-protein phosphatase-like N

Protein Summary
Description
Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). ICA512-transmembran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295718
  • ENSP00000295718
  • ENSG00000054356
  • ENST00000409251
  • ENSP00000386638
  • ENST00000423636
  • ENSP00000392598

Symbol
  • ICA3
  • ICA512
  • IA2
  • IA-2
  • ICA512
  • R-PTP-N
  • IA-2/PTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
biological process
0.61
PubMedID
0.56
biological term
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1210.56   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1210.56   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
47.5
mean reticulocyte volume
1
1
1
38.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
47.5
mean reticulocyte volume
1
38.6
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type N
VGNC:6372
459962
Mouse
MGI:102765
19275
Rat
RGD:620777
116660
Dog
protein tyrosine phosphatase, receptor type N
VGNC:45193
478921
Horse
protein tyrosine phosphatase, receptor type N
VGNC:22036
100056346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type N
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type N
Horse
protein tyrosine phosphatase, receptor type N
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16849-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (105)
1 – 10 of 105
MICAL2
Tbio
Family: Enzyme
Novelty: 0.12186673
p_int: 0.999999538
p_ni: 2.09e-7
p_wrong: 2.53e-7
Score: 0.289
Data Source: BioPlex,STRINGDB
SGSM2
Tbio
Novelty: 0.19530845
p_int: 0.999999259
p_ni: 2.49e-7
p_wrong: 4.92e-7
Score: 0.396
Data Source: BioPlex,STRINGDB
CCDC51
Tdark
Novelty: 1.19203634
p_int: 0.999967763
p_ni: 0.000032207
p_wrong: 3e-8
Data Source: BioPlex
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
p_int: 0.999958475
p_ni: 0.000041525
p_wrong: 1e-9
Score: 0.542
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.999127301
p_ni: 0.000872699
Score: 0.222
Data Source: BioPlex,STRINGDB
PTPRN2
Tbio
Family: Enzyme
Novelty: 0.00862854
p_int: 0.989771955
p_wrong: 0.010228045
Score: 0.906
Data Source: BioPlex,STRINGDB
MFSD8
Tbio
Novelty: 0.03388459
p_int: 0.984643185
p_ni: 0.006640235
p_wrong: 0.008716581
Score: 0.165
Data Source: BioPlex,STRINGDB
HLA-F
Tbio
Novelty: 0.01200285
p_int: 0.98185816
p_ni: 0.01814184
Score: 0.188
Data Source: BioPlex,STRINGDB
CYB5D2
Tbio
Novelty: 0.23122479
p_int: 0.944508685
p_ni: 0.055491315
Score: 0.18
Data Source: BioPlex,STRINGDB
ADPGK
Tbio
Family: Kinase
Novelty: 0.0552414
p_int: 0.938903887
p_ni: 0.061096113
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1210.56

PubMed score by year
PubTator Score  718.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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