You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PTPRN
Receptor-type tyrosine-protein phosphatase-like N

Protein Summary
Description
Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). ICA512-transmembran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295718
  • ENSP00000295718
  • ENSG00000054356
  • ENST00000409251
  • ENSP00000386638
  • ENST00000423636
  • ENSP00000392598

Symbol
  • ICA3
  • ICA512
  • IA2
  • IA-2
  • ICA512
  • R-PTP-N
  • IA-2/PTP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
biological process
0.61
PubMedID
0.56
biological term
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 800.4   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 800.4   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (105)
1 – 10 of 105
MICAL2
Tbio
Family: Enzyme
Novelty: 0.22235633
p_int: 0.999999538
p_ni: 2.09e-7
p_wrong: 2.53e-7
Score: 0.289
Data Source: BioPlex,STRINGDB
SGSM2
Tbio
Novelty: 0.31778726
p_int: 0.999999259
p_ni: 2.49e-7
p_wrong: 4.92e-7
Score: 0.396
Data Source: BioPlex,STRINGDB
CCDC51
Tdark
Novelty: 1.55555556
p_int: 0.999967763
p_ni: 0.000032207
p_wrong: 3e-8
Data Source: BioPlex
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00370934
p_int: 0.999958475
p_ni: 0.000041525
p_wrong: 1e-9
Score: 0.542
Data Source: BioPlex,STRINGDB
TMEM214
Tdark
Novelty: 1.5
p_int: 0.999127301
p_ni: 0.000872699
Score: 0.222
Data Source: BioPlex,STRINGDB
PTPRN2
Tbio
Family: Enzyme
Novelty: 0.00328446
p_int: 0.989771955
p_wrong: 0.010228045
Score: 0.906
Data Source: BioPlex,STRINGDB
MFSD8
Tbio
Novelty: 0.01280168
p_int: 0.984643185
p_ni: 0.006640235
p_wrong: 0.008716581
Score: 0.165
Data Source: BioPlex,STRINGDB
HLA-F
Tbio
Novelty: 0.01349191
p_int: 0.98185816
p_ni: 0.01814184
Score: 0.188
Data Source: BioPlex,STRINGDB
CYB5D2
Tdark
Novelty: 0.25907026
p_int: 0.944508685
p_ni: 0.055491315
Score: 0.18
Data Source: BioPlex,STRINGDB
ADPGK
Tbio
Family: Kinase
Novelty: 0.11313548
p_int: 0.938903887
p_ni: 0.061096113
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  800.40

PubMed score by year
PubTator Score  718.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: