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Tbio
HADH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

Protein Summary
Description
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA. This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309522
  • ENSP00000312288
  • ENSG00000138796
  • ENST00000603302
  • ENSP00000474560

Symbol
  • HAD
  • HADHSC
  • SCHAD
  • HAD
  • HCDH
  • HHF4
  • HADH1
  • SCHAD
  • HADHSC
  • MSCHAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
1
virus perturbation
0.94
protein domain
0.92
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.79   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.79   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
ECHS1
Tbio
Family:  Enzyme
Novelty:  0.01291476
Score:  0.997
Data Source:  STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.995
Data Source:  STRINGDB
HADHB
Tbio
Family:  Enzyme
Novelty:  0.00969194
Score:  0.995
Data Source:  STRINGDB
ACAT1
Tchem
Family:  Enzyme
Novelty:  0.00908928
Score:  0.991
Data Source:  STRINGDB
ACAT2
Tchem
Family:  Enzyme
Novelty:  0.01464168
Score:  0.991
Data Source:  STRINGDB
ACAA2
Tbio
Family:  Enzyme
Novelty:  0.01452373
Score:  0.989
Data Source:  STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.975
Data Source:  STRINGDB
SCP2
Tchem
Novelty:  0.00183736
Score:  0.974
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.971
Data Source:  STRINGDB
OXCT1
Tbio
Family:  Enzyme
Novelty:  0.00283394
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
Pathways (30)
Beta oxidation of butanoyl-CoA to acetyl-CoA (R-HSA-77352)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta oxidation of butanoyl-CoA to acetyl-CoA
Reactome
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Reactome
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Reactome
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Reactome
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Name
Explore in Pharos
Explore in Source
Beta oxidation of butanoyl-CoA to acetyl-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
71.9
2
2
0
1.2
53.1
hair color
1
1
0
1.3
33.1
Calcium channel blocker use measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
71.9
0
1.2
53.1
hair color
0
1.3
33.1
Calcium channel blocker use measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase
VGNC:48900
461424
Macaque
hydroxyacyl-CoA dehydrogenase
696181
Mouse
MGI:96009
15107
Rat
RGD:69321
113965
Dog
hydroxyacyl-CoA dehydrogenase
VGNC:41584
478506
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxyacyl-CoA dehydrogenase
Macaque
hydroxyacyl-CoA dehydrogenase
Mouse
Rat
Dog
hydroxyacyl-CoA dehydrogenase
Publication Statistics
PubMed Score 267.79
PubMed score by year
PubTator Score 91.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title