HADH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Protein Summary
Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA. This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]
- ENST00000309522
- ENSP00000312288
- ENSG00000138796
- ENST00000603302
- ENSP00000474560
- HAD
- HADHSC
- SCHAD
- HAD
- HCDH
- HHF4
- HADH1
- SCHAD
- HADHSC
- MSCHAD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.94 | ||
protein domain | 0.92 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 434.11 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 496 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 434.11 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 496 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0