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Tchem
DDR2
Discoidin domain-containing receptor 2

Protein Summary
Description
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367921
  • ENSP00000356898
  • ENSG00000162733
  • ENST00000367922
  • ENSP00000356899
  • ENST00000446985
  • ENSP00000400309

Symbol
  • NTRKR3
  • TKT
  • TYRO10
  • TKT
  • WRCN
  • MIG20a
  • NTRKR3
  • TYRO10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.99
virus perturbation
0.95
biological process
0.87
disease perturbation
0.83


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.15   (req: < 5)
Gene RIFs: 82   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 314.15   (req: >= 5)
Gene RIFs: 82   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Active Ligands (33)
1 – 10 of 33
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CHEMBL103667
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sitravatinib
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CHEMBL1908391
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CHEMBL1688860,CHEMBL3764357
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CHEMBL1688861,CHEMBL3764895
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GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
77.2
Dupuytren Contracture
1
1
0
1.2
45.4
body height
1
1
1
14.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
77.2
Dupuytren Contracture
0
1.2
45.4
body height
1
14.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
discoidin domain receptor tyrosine kinase 2
VGNC:520
457467
Macaque
discoidin domain receptor tyrosine kinase 2
720124
Mouse
MGI:1345277
18214
Rat
RGD:619855
685781
Dog
discoidin domain receptor tyrosine kinase 2
VGNC:39842
478987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
discoidin domain receptor tyrosine kinase 2
Macaque
discoidin domain receptor tyrosine kinase 2
Mouse
Rat
Dog
discoidin domain receptor tyrosine kinase 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16832-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Non-integrin membrane-ECM interactions
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Non-integrin membrane-ECM interactions
Gene Ontology Terms (35)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.766
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.75
Data Source: STRINGDB
MMP13
Tchem
Family: Enzyme
Novelty: 0.00057893
Score: 0.731
Data Source: STRINGDB
MMP2
Tchem
Family: Enzyme
Novelty: 0.00012762
Score: 0.679
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.667
Data Source: STRINGDB
ITGA2
Tbio
Novelty: 0.0013482
Score: 0.65
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.648
Data Source: STRINGDB
UAP1
Tbio
Family: Enzyme
Novelty: 0.02034314
Score: 0.644
Data Source: STRINGDB
PAWR
Tbio
Novelty: 0.01108457
Score: 0.629
Data Source: STRINGDB
POSTN
Tbio
Novelty: 0.00108629
Score: 0.627
Data Source: STRINGDB
Publication Statistics
PubMed Score  314.15

PubMed score by year
PubTator Score  130.65

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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