Protein Summary
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate (PubMed:7488099). The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]
- ENST00000331803
- ENSP00000330032
- ENSG00000183696
- ENST00000395560
- ENSP00000378927
- ENST00000395564
- ENSP00000378931
- ENST00000417464
- ENSP00000413611
- ENST00000457596
- ENSP00000408899
- UP
- UP
- UPP
- UPASE
- UDRPASE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
gene perturbation | 0.94 | ||
transcription factor binding site profile | 0.91 | ||
small molecule perturbation | 0.81 | ||
biological process | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.17 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 85.17 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0