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Tbio
DUSP7
Dual specificity protein phosphatase 7

Protein Summary
Description
Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000495880
  • ENSP00000417183
  • ENSG00000164086

Symbol
  • PYST2
  • MKPX
  • PYST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.91
transcription factor
0.87
transcription factor binding site profile
0.84
biological process
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
DUSP9
Tbio
Family:  Enzyme
Novelty:  0.03849148
p_int:  0.999999902
p_wrong:  9.8e-8
Score:  0.903
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999998932
p_ni:  2.59e-7
p_wrong:  8.09e-7
Score:  0.933
Data Source:  BioPlex,STRINGDB
CDK18
Tchem
Family:  Kinase
Novelty:  0.053383
p_int:  0.998168405
p_ni:  0.001831594
p_wrong:  2e-9
Score:  0.329
Data Source:  BioPlex,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.992
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.987
Data Source:  Reactome,STRINGDB
MAPK7
Tchem
Family:  Kinase
Novelty:  0.00257226
Score:  0.961
Data Source:  Reactome,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.893
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.823
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.813
Data Source:  STRINGDB
PTPRR
Tbio
Family:  Enzyme
Novelty:  0.02065754
Score:  0.802
Data Source:  STRINGDB
Pathways (41)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ERKs are inactivated
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ERKs are inactivated
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
69.4
BMI-adjusted waist circumference
1
1
1
50.6
macrophage inflammatory protein 1b measurement
1
2
2
47.5
waist circumference
1
1
1
21.5
low density lipoprotein cholesterol measurement
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
69.4
BMI-adjusted waist circumference
1
50.6
macrophage inflammatory protein 1b measurement
2
47.5
waist circumference
1
21.5
low density lipoprotein cholesterol measurement
1
7.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 7
VGNC:11384
470826
Macaque
dual specificity phosphatase 7 [Source:HGNC Symbol;Acc:HGNC:3073]
Mouse
MGI:2387100
235584
Rat
RGD:735026
300980
Dog
dual specificity phosphatase 7
VGNC:40136
484742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 7
Macaque
dual specificity phosphatase 7 [Source:HGNC Symbol;Acc:HGNC:3073]
Mouse
Rat
Dog
dual specificity phosphatase 7
Publication Statistics
PubMed Score 17.65
PubMed score by year
PubTator Score 10.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title