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Tbio
DUSP7
Dual specificity protein phosphatase 7

Protein Summary
Description
Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity). Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000495880
  • ENSP00000417183
  • ENSG00000164086

Symbol
  • PYST2
  • MKPX
  • PYST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.91
transcription factor
0.87
transcription factor binding site profile
0.84
biological process
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (41)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ERKs are inactivated
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ERKs are inactivated
FLT3 Signaling
Immune System
Protein-Protein Interactions (46)
1 – 10 of 46
DUSP9
Tbio
Family: Enzyme
Novelty: 0.03849148
p_int: 0.999999902
p_wrong: 9.8e-8
Score: 0.903
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999998932
p_ni: 2.59e-7
p_wrong: 8.09e-7
Score: 0.933
Data Source: BioPlex,STRINGDB
CDK18
Tchem
Family: Kinase
Novelty: 0.053383
p_int: 0.998168405
p_ni: 0.001831594
p_wrong: 2e-9
Score: 0.329
Data Source: BioPlex,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.992
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.987
Data Source: Reactome,STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.961
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.893
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.823
Data Source: STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
Score: 0.813
Data Source: STRINGDB
PTPRR
Tbio
Family: Enzyme
Novelty: 0.02065754
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.48

PubMed score by year
PubTator Score  10.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer