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Tbio
DUSP6
Dual specificity protein phosphatase 6

Protein Summary
Description
Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279488
  • ENSP00000279488
  • ENSG00000139318
  • ENST00000308385
  • ENSP00000307835

Symbol
  • MKP3
  • PYST1
  • HH19
  • MKP3
  • PYST1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
transcription factor perturbation
0.97
biological process
0.94
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.8   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 499   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.8   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 499   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
89.3
cognitive function measurement
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
89.3
cognitive function measurement
1
63.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 6
VGNC:13056
452115
Macaque
dual specificity phosphatase 6
708907
Mouse
MGI:1914853
67603
Rat
RGD:70978
116663
Dog
dual specificity phosphatase 6
VGNC:40135
482594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dual specificity phosphatase 6
Macaque
dual specificity phosphatase 6
Mouse
Rat
Dog
dual specificity phosphatase 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (49)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
ERK/MAPK targets
Reactome
ERKs are inactivated
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
ERK/MAPK targets
ERKs are inactivated
FLT3 Signaling
Immune System
Protein-Protein Interactions (107)
1 – 10 of 107
FAM217B
Tdark
Novelty: 4.03122155
p_int: 0.999811784
p_ni: 0.000188147
p_wrong: 6.9e-8
Score: 0.622
Data Source: BioPlex,STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.998
Data Source: Reactome,STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.00012969
Score: 0.996
Data Source: Reactome,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
Score: 0.979
Data Source: STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.966
Data Source: Reactome,STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.965
Data Source: STRINGDB
DUSP1
Tchem
Family: Enzyme
Novelty: 0.00097955
Score: 0.919
Data Source: STRINGDB
DUSP4
Tbio
Family: Enzyme
Novelty: 0.00952421
Score: 0.917
Data Source: STRINGDB
DUSP8
Tbio
Family: Enzyme
Novelty: 0.0105002
Score: 0.915
Data Source: STRINGDB
DUSP2
Tbio
Family: Enzyme
Novelty: 0.03459749
Score: 0.91
Data Source: STRINGDB
Publication Statistics
PubMed Score  260.80

PubMed score by year
PubTator Score  136.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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