Tbio PCK2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Protein Summary

Description

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q16822
• B4DW73
• O43253
• Q86U01
• Q9BV62
• PEPCK-M

Gene Name

• PCK2

Ensembl ID

• ENST00000216780
• ENSP00000216780
• ENSG00000100889
• ENST00000396973
• ENSP00000380171
• ENST00000545054
• ENSP00000441826
• ENST00000561286
• ENSP00000454011
• ENST00000644679
• ENSP00000496102
• ENSG00000285241
• ENST00000645217
• ENSP00000494919
• ENST00000645536
• ENSP00000496343
• ENST00000645709
• ENSP00000494029

Symbol

• PEPCK2
• PEPCK
• PEPCK2
• PEPCK-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.93
transcription factor perturbation	0.88
biological process	0.8
small molecule perturbation	0.77

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Phosphoenolpyruvate Carboxykinase [Gtp] Family / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.08   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.08   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (202)

Explore Interacting Targets

1 – 10 of 202

• See Interactions on String-DB

PCK1

Tbio

Family:  Kinase

Novelty:  0.0033726

p_int:  0.999999388

p_ni:  1.8e-8

p_wrong:  5.93e-7

Score:  0.856

Data Source:  BioPlex,STRINGDB

MUC5B

Tbio

Novelty:  0.000832

p_int:  0.999998673

p_ni:  0.000001327

Score:  0.187

Data Source:  BioPlex,STRINGDB

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999996458

p_ni:  0.000003542

Score:  0.177

Data Source:  BioPlex,STRINGDB

DMBT1

Tbio

Novelty:  0.00357297

p_int:  0.999920634

p_ni:  0.000079366

Score:  0.17

Data Source:  BioPlex,STRINGDB

BPIFA1

Tbio

Novelty:  0.00586117

p_int:  0.999865191

p_ni:  0.000028069

p_wrong:  0.00010674

Score:  0.169

Data Source:  BioPlex,STRINGDB

IGHA2

Tbio

p_int:  0.999710039

p_ni:  0.000289914

p_wrong:  4.7e-8

Data Source:  BioPlex

ZMYM2

Tbio

Novelty:  0.0258698

p_int:  0.995990299

p_ni:  0.004009701

Data Source:  BioPlex

PIGR

Tbio

Novelty:  0.0025812

p_int:  0.985646675

p_ni:  0.014339052

p_wrong:  0.000014273

Score:  0.186

Data Source:  BioPlex,STRINGDB

AHNAK2

Tbio

Novelty:  0.05663435

p_int:  0.976010109

p_ni:  0.023989891

Data Source:  BioPlex

IGHA1

Tbio

p_int:  0.967813061

p_ni:  0.032186924

p_wrong:  1.5e-8

Data Source:  BioPlex

Nearest Tclin Targets (7)

Explore Nearest Tclin Targets

Upstream (7)

1 – 5 of 7

JAK2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  2

1: PI3K-Akt signaling pathway

2: Adipocytokine signaling pathway

IL6

Tclin

Family:  Other

KEGG Distance:  3

Common Pathways:  3

1: PI3K-Akt signaling pathway

2: Insulin resistance

3: FoxO signaling pathway

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: PI3K-Akt signaling pathway

2: FoxO signaling pathway

3: Insulin signaling pathway

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  3

1: PI3K-Akt signaling pathway

2: FoxO signaling pathway

3: Insulin signaling pathway

INSR

Tclin

Family:  Kinase

KEGG Distance:  3

Common Pathways:  5

1: PI3K-Akt signaling pathway

2: Insulin resistance

3: FoxO signaling pathway

4: AMPK signaling pathway

5: Insulin signaling pathway

Pathways (95)

Reactome (4)

KEGG (13)

PathwayCommons (2)

UniProt (1)

WikiPathways (75)

Gluconeogenesis (R-HSA-70263)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gluconeogenesis	34 targets	R-HSA-70263
Reactome	Glucose metabolism	92 targets	R-HSA-70326
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387

Name	Explore in Pharos	Explore in Source
Gluconeogenesis	34 targets	R-HSA-70263
Glucose metabolism	92 targets	R-HSA-70326
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (4)

Components (3)

Processes (10)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
manganese ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphoenolpyruvate carboxykinase (GTP) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphoenolpyruvate carboxykinase activity	Traceable Author Statement (TAS)	ProtInc
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (18)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	ENSG00000285241	1	1	1		55.2
self reported educational attainment	EFO_0004784	ENSG00000100889	1	1	1		55.2
liver disease biomarker	EFO_0006845	ENSG00000285241	1	1	1		48.5
liver fat measurement	EFO_0010821	ENSG00000100889	1	1	1		48.5
liver disease biomarker	EFO_0006845	ENSG00000100889	1	1	1		48.5

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		55.2
self reported educational attainment	EFO_0004784	1		55.2
liver disease biomarker	EFO_0006845	1		48.5
liver fat measurement	EFO_0010821	1		48.5
liver disease biomarker	EFO_0006845	1		48.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Decarboxylase
Gluconeogenesis
GTP-binding
Lyase
Manganese
Metal-binding
Mitochondrion

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
cognitive function measurement
liver disease biomarker
liver fat measurement
mean corpuscular volume
red blood cell density measurement
self reported educational attainment
smoking status measurement
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:8219	452807
Macaque	phosphoenolpyruvate carboxykinase 2, mitochondrial		714922
Mouse	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	MGI:1860456	74551
Dog	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:44308	480255
Horse	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:21204	100054903

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphoenolpyruvate carboxykinase 2, mitochondrial
Macaque	phosphoenolpyruvate carboxykinase 2, mitochondrial
Mouse	phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Dog	phosphoenolpyruvate carboxykinase 2, mitochondrial
Horse	phosphoenolpyruvate carboxykinase 2, mitochondrial

Publication Statistics

PubMed Score 260.08

PubMed score by year

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PubTator Score 272.63

PubTator score by year

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Patents

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Related Publications

Text Mined References (31)

GeneRif Annotations (19)

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10

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PMID	Year	Title