Tbio PCK2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Phosphoenolpyruvate Carboxykinase [Gtp] Family / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

Protein Summary

Description

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q16822
• B4DW73
• O43253
• Q86U01
• Q9BV62
• PEPCK-M

Gene Name

• PCK2

Ensembl ID

• ENST00000216780
• ENSP00000216780
• ENSG00000100889
• ENST00000396973
• ENSP00000380171
• ENST00000545054
• ENSP00000441826
• ENST00000561286
• ENSP00000454011
• ENST00000644679
• ENSP00000496102
• ENSG00000285241
• ENST00000645217
• ENSP00000494919
• ENST00000645536
• ENSP00000496343
• ENST00000645709
• ENSP00000494029

Symbol

• PEPCK2
• PEPCK
• PEPCK2
• PEPCK-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.93
transcription factor perturbation	0.88
biological process	0.8
small molecule perturbation	0.77

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.08   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.08   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (18)

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5

1 – 5 of 18

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	ENSG00000285241	1	1	1		55.2
self reported educational attainment	EFO_0004784	ENSG00000100889	1	1	1		55.2
liver fat measurement	EFO_0010821	ENSG00000100889	1	1	1		48.5
liver disease biomarker	EFO_0006845	ENSG00000285241	1	1	1		48.5
liver disease biomarker	EFO_0006845	ENSG00000100889	1	1	1		48.5

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
self reported educational attainment	EFO_0004784	1		55.2
self reported educational attainment	EFO_0004784	1		55.2
liver fat measurement	EFO_0010821	1		48.5
liver disease biomarker	EFO_0006845	1		48.5
liver disease biomarker	EFO_0006845	1		48.5

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:8219	452807
Macaque	phosphoenolpyruvate carboxykinase 2, mitochondrial		714922
Mouse	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	MGI:1860456	74551
Dog	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:44308	480255
Horse	phosphoenolpyruvate carboxykinase 2, mitochondrial	VGNC:21204	100054903

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphoenolpyruvate carboxykinase 2, mitochondrial
Macaque	phosphoenolpyruvate carboxykinase 2, mitochondrial
Mouse	phosphoenolpyruvate carboxykinase 2 (mitochondrial)
Dog	phosphoenolpyruvate carboxykinase 2, mitochondrial
Horse	phosphoenolpyruvate carboxykinase 2, mitochondrial

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q16822-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (95)

Reactome (4)

KEGG (13)

PathwayCommons (2)

UniProt (1)

WikiPathways (75)

Gluconeogenesis (R-HSA-70263)

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Find Similar Targets

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gluconeogenesis	34 targets	R-HSA-70263
Reactome	Glucose metabolism	92 targets	R-HSA-70326
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of carbohydrates	293 targets	R-HSA-71387

Name	Explore in Pharos	Explore in Source
Gluconeogenesis	34 targets	R-HSA-70263
Glucose metabolism	92 targets	R-HSA-70326
Metabolism	2112 targets	R-HSA-1430728
Metabolism of carbohydrates	293 targets	R-HSA-71387

Gene Ontology Terms (17)

Functions (4)

Components (3)

Processes (10)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
manganese ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphoenolpyruvate carboxykinase (GTP) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
phosphoenolpyruvate carboxykinase activity	Traceable Author Statement (TAS)	ProtInc
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (202)

Explore Interacting Targets

1 – 10 of 202

• See Interactions on String-DB

PCK1

Tbio

Family:  Kinase

Novelty:  0.0033726

p_int:  0.999999388

p_ni:  1.8e-8

p_wrong:  5.93e-7

Score:  0.856

Data Source:  BioPlex,STRINGDB

MUC5B

Tbio

Novelty:  0.000832

p_int:  0.999998673

p_ni:  0.000001327

Score:  0.187

Data Source:  BioPlex,STRINGDB

BPIFB1

Tbio

Novelty:  0.03980683

p_int:  0.999996458

p_ni:  0.000003542

Score:  0.177

Data Source:  BioPlex,STRINGDB

DMBT1

Tbio

Novelty:  0.00357297

p_int:  0.999920634

p_ni:  0.000079366

Score:  0.17

Data Source:  BioPlex,STRINGDB

BPIFA1

Tbio

Novelty:  0.00586117

p_int:  0.999865191

p_ni:  0.000028069

p_wrong:  0.00010674

Score:  0.169

Data Source:  BioPlex,STRINGDB

IGHA2

Tbio

p_int:  0.999710039

p_ni:  0.000289914

p_wrong:  4.7e-8

Data Source:  BioPlex

ZMYM2

Tbio

Novelty:  0.0258698

p_int:  0.995990299

p_ni:  0.004009701

Data Source:  BioPlex

PIGR

Tbio

Novelty:  0.0025812

p_int:  0.985646675

p_ni:  0.014339052

p_wrong:  0.000014273

Score:  0.186

Data Source:  BioPlex,STRINGDB

AHNAK2

Tbio

Novelty:  0.05663435

p_int:  0.976010109

p_ni:  0.023989891

Data Source:  BioPlex

IGHA1

Tbio

p_int:  0.967813061

p_ni:  0.032186924

p_wrong:  1.5e-8

Data Source:  BioPlex

Publication Statistics

PubMed Score  260.08

PubMed score by year

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PubTator Score  272.63

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Decarboxylase
Gluconeogenesis
GTP-binding
Lyase
Manganese
Metal-binding
Mitochondrion

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
cognitive function measurement
liver disease biomarker
liver fat measurement
mean corpuscular volume
red blood cell density measurement
self reported educational attainment
smoking status measurement
triglyceride measurement