Tbio PCK2 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Protein Summary

Description

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• Q16822
• B4DW73
• O43253
• Q86U01
• Q9BV62
• PEPCK-M

Gene Name

• PCK2

Ensembl ID

• ENST00000216780
• ENSP00000216780
• ENSG00000100889
• ENST00000396973
• ENSP00000380171
• ENST00000545054
• ENSP00000441826
• ENST00000561286
• ENSP00000454011
• ENST00000644679
• ENSP00000496102
• ENSG00000285241
• ENST00000645217
• ENSP00000494919
• ENST00000645536
• ENSP00000496343
• ENST00000645709
• ENSP00000494029

Symbol

• PEPCK2
• PEPCK
• PEPCK2
• PEPCK-M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.93
transcription factor perturbation	0.88
biological process	0.8
small molecule perturbation	0.77

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

DTO Classes

Protein / Kinase / Non-protein Kinase / Other Small Molecule Kinase / Phosphoenolpyruvate Carboxykinase [Gtp] Family / Phosphoenolpyruvate Carboxykinase [Gtp], Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.12   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 293.12   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0