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Tbio
PCK2
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

Protein Summary
Description
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216780
  • ENSP00000216780
  • ENSG00000100889
  • ENST00000396973
  • ENSP00000380171
  • ENST00000545054
  • ENSP00000441826
  • ENST00000561286
  • ENSP00000454011
  • ENST00000644679
  • ENSP00000496102
  • ENSG00000285241
  • ENST00000645217
  • ENSP00000494919
  • ENST00000645536
  • ENSP00000496343
  • ENST00000645709
  • ENSP00000494029

Symbol
  • PEPCK2
  • PEPCK
  • PEPCK2
  • PEPCK-M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
molecular function
0.93
transcription factor perturbation
0.88
biological process
0.8
small molecule perturbation
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.16   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.16   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
liver fat measurement
1
1
1
61.4
liver fat measurement
1
1
1
61.4
liver disease biomarker
1
1
1
61.4
liver disease biomarker
1
1
1
61.4
smoking status measurement
1
1
1
39.9
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
liver fat measurement
1
61.4
liver fat measurement
1
61.4
liver disease biomarker
1
61.4
liver disease biomarker
1
61.4
smoking status measurement
1
39.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphoenolpyruvate carboxykinase 2, mitochondrial
VGNC:8219
452807
Macaque
phosphoenolpyruvate carboxykinase 2, mitochondrial
714922
Mouse
MGI:1860456
74551
Dog
phosphoenolpyruvate carboxykinase 2, mitochondrial
VGNC:44308
480255
Horse
phosphoenolpyruvate carboxykinase 2, mitochondrial
VGNC:21204
100054903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphoenolpyruvate carboxykinase 2, mitochondrial
Macaque
phosphoenolpyruvate carboxykinase 2, mitochondrial
Mouse
Dog
phosphoenolpyruvate carboxykinase 2, mitochondrial
Horse
phosphoenolpyruvate carboxykinase 2, mitochondrial
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16822-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (95)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (202)
1 – 10 of 202
PCK1
Tbio
Family: Kinase
Novelty: 0.0033726
p_int: 0.999999388
p_ni: 1.8e-8
p_wrong: 5.93e-7
Score: 0.856
Data Source: BioPlex,STRINGDB
MUC5B
Tbio
Novelty: 0.000832
p_int: 0.999998673
p_ni: 0.000001327
Score: 0.187
Data Source: BioPlex,STRINGDB
BPIFB1
Tbio
Novelty: 0.03980683
p_int: 0.999996458
p_ni: 0.000003542
Score: 0.177
Data Source: BioPlex,STRINGDB
DMBT1
Tbio
Novelty: 0.00357297
p_int: 0.999920634
p_ni: 0.000079366
Score: 0.17
Data Source: BioPlex,STRINGDB
BPIFA1
Tbio
Novelty: 0.00586117
p_int: 0.999865191
p_ni: 0.000028069
p_wrong: 0.00010674
Score: 0.169
Data Source: BioPlex,STRINGDB
IGHA2
Tbio
p_int: 0.999710039
p_ni: 0.000289914
p_wrong: 4.7e-8
Data Source: BioPlex
ZMYM2
Tbio
Novelty: 0.0258698
p_int: 0.995990299
p_ni: 0.004009701
Data Source: BioPlex
PIGR
Tbio
Novelty: 0.0025812
p_int: 0.985646675
p_ni: 0.014339052
p_wrong: 0.000014273
Score: 0.186
Data Source: BioPlex,STRINGDB
AHNAK2
Tbio
Novelty: 0.05663435
p_int: 0.976010109
p_ni: 0.023989891
Data Source: BioPlex
IGHA1
Tbio
p_int: 0.967813061
p_ni: 0.032186924
p_wrong: 1.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  249.16

PubMed score by year
PubTator Score  272.63

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer