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Tbio
PPP1R3A
Protein phosphatase 1 regulatory subunit 3A

Protein Summary
Description
Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase (By similarity). The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284601
  • ENSP00000284601
  • ENSG00000154415
  • ENST00000284602
  • ENSP00000284602

Symbol
  • PP1G
  • GM
  • PP1G
  • PPP1R3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.6
cell line
0.56
gene perturbation
0.52
hub protein
0.49
biological term
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.03   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.96
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.936
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.918
Data Source:  STRINGDB
INSR
Tclin
Family:  Kinase
Novelty:  0.00230617
Score:  0.918
Data Source:  STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.904
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.892
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.855
Data Source:  STRINGDB
PPP1R3E
Tdark
Family:  Enzyme
Novelty:  1.19260521
Score:  0.853
Data Source:  STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
Score:  0.845
Data Source:  STRINGDB
PPP1R3D
Tdark
Family:  Enzyme
Novelty:  0.53609018
Score:  0.843
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
1
1
54.4
IGF-1 measurement
1
1
1
42.3
glomerular filtration rate
1
1
1
35
household income
1
1
1
30.2
grip strength measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gait measurement
1
54.4
IGF-1 measurement
1
42.3
glomerular filtration rate
1
35
household income
1
30.2
grip strength measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3A
VGNC:4478
463666
Macaque
protein phosphatase 1 regulatory subunit 3A
703562
Mouse
MGI:2153588
140491
Rat
RGD:1561312
500036
Dog
protein phosphatase 1 regulatory subunit 3A
VGNC:44896
482411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3A
Macaque
protein phosphatase 1 regulatory subunit 3A
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 3A
Publication Statistics
PubMed Score 28.03
PubMed score by year
PubTator Score 191.15
PubTator score by year
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Related Publications
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PMID
Year
Title