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Tchem
PHKG1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform

Protein Summary
Description
Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity). This gene is a member of the Ser/Thr protein kinase family and encodes a protein with one protein kinase domain and two calmodulin-binding domains. This protein is the catalytic member of a 16 subunit protein kinase complex which contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. This gene has two pseudogenes at chromosome 7q11.21 and one at chromosome 11p11.12. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297373
  • ENSP00000297373
  • ENSG00000164776
  • ENST00000452681
  • ENSP00000445440

Symbol
  • PHKG
  • PHKG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.92
cell type or tissue
0.76
gene perturbation
0.75
PubMedID
0.64


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
IDG Resources
NanoBRET
image for NanoLuc®-PHKG1
  • Institute:  UNC-CH
  • Authors:  Julie Pickett
  • PI:  Tim Willson
  • Assay ID:  BAO_0010069
  • Endpoint:  fold change
  • Endpoint Detection:  fluorescence intensity
  • Repository:  Synapse
NanoBRET
image for NanoLuc®-fused PHKG1
Approved Drugs (1)
1 – 1 of 1
sunitinib
Rendered image for sunitinib
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
11
19
94.4
glycine measurement
3
2
3
90.8
blood metabolite measurement
2
1
2
69.8
myeloid white cell count
1
1
1
66.3
lymphocyte count
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
19
94.4
glycine measurement
3
90.8
blood metabolite measurement
2
69.8
myeloid white cell count
1
66.3
lymphocyte count
1
64.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase catalytic subunit gamma 1
VGNC:9067
746486
Macaque
phosphorylase kinase catalytic subunit gamma 1
703091
Mouse
MGI:97579
18682
Rat
RGD:3325
29353
Dog
phosphorylase kinase catalytic subunit gamma 1
VGNC:44499
489784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphorylase kinase catalytic subunit gamma 1
Macaque
phosphorylase kinase catalytic subunit gamma 1
Mouse
Rat
Dog
phosphorylase kinase catalytic subunit gamma 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16816-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Glycogen breakdown (glycogenolysis) (R-HSA-70221)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycogen breakdown (glycogenolysis)
Reactome
Glycogen metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycogen breakdown (glycogenolysis)
Glycogen metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (52)
1 – 10 of 52
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  1
Score:  0.876
Data Source:  BioPlex,STRINGDB
PHKB
Tbio
Family:  Enzyme
Novelty:  0.05506418
Score:  0.985
Data Source:  Reactome,STRINGDB
PHKA1
Tbio
Family:  Kinase
Novelty:  0.02895127
Score:  0.981
Data Source:  Reactome,STRINGDB
PYGM
Tchem
Family:  Enzyme
Novelty:  0.00507768
Score:  0.975
Data Source:  Reactome,STRINGDB
PHKA2
Tbio
Family:  Kinase
Novelty:  0.00461145
Score:  0.975
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.966
Data Source:  Reactome,STRINGDB
PYGB
Tchem
Family:  Enzyme
Novelty:  0.00224148
Score:  0.956
Data Source:  Reactome,STRINGDB
CALML6
Tbio
Novelty:  0.17113396
Score:  0.837
Data Source:  STRINGDB
PYGL
Tchem
Family:  Enzyme
Novelty:  0.01157477
Score:  0.829
Data Source:  STRINGDB
CALML4
Tdark
Novelty:  0.44764047
Score:  0.827
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.28

PubMed score by year
PubTator Score  5.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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