Tbio LAMA3 Laminin subunit alpha-3

Protein Summary

Description

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. The protein encoded by this gene belongs to the laminin family of secreted molecules. Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. This gene encodes an alpha subunit and is responsive to several epithelial-mesenchymal regulators including keratinocyte growth factor, epidermal growth factor and insulin-like growth factor. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa and laryngoonychocutaneous syndrome. Alternative splicing and alternative promoter usage result in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q16787
• B0YJ33
• Q13679
• Q13680
• Q6VU67
• Q6VU68
• Q6VU69
• Q76E14
• Q96TG0

Gene Name

• LAMA3

Ensembl ID

• ENST00000313654
• ENSP00000324532
• ENSG00000053747

Symbol

• LAMNA
• E170
• LOCS
• BM600
• LAMNA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
cell type or tissue	0.8
virus perturbation	0.79
histone modification site profile	0.77
small molecule perturbation	0.75

Protein Classes

PANTHER Classes

Protein / Receptor / Laminin Subunit Alpha-3

Protein / Extracellular Matrix Protein / Extracellular Matrix Linker Protein / Laminin Subunit Alpha-3

Protein / ... / Protease Inhibitor / Laminin Subunit Alpha-3

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Laminin Subunit Alpha-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.18   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.18   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0