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Tbio
HIST2H2BE
Histone H2B type 2-E

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369155
  • ENSP00000358151
  • ENSG00000184678

Symbol
  • H2BFQ
  • H2B
  • H2BQ
  • GL105
  • H2B.1
  • H2BFQ
  • H2BGL105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
cell type or tissue
0.96
histone modification site profile
0.92
gene perturbation
0.84
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3819.62   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3819.62   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (618)
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.999
Data Source:  STRINGDB
HIST2H2AA3
Tbio
Novelty:  0.00065445
Score:  0.996
Data Source:  STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.993
Data Source:  STRINGDB
HIST1H2AC
Tdark
Novelty:  0.4785744
Score:  0.99
Data Source:  STRINGDB
HIST3H2A
Tbio
Novelty:  0.34036249
Score:  0.989
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.988
Data Source:  STRINGDB
CENPA
Tbio
Novelty:  0.00154245
Score:  0.988
Data Source:  STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
Score:  0.988
Data Source:  STRINGDB
TP53BP1
Tbio
Family:  Epigenetic
Novelty:  0.00131256
Score:  0.987
Data Source:  STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (92)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 87
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
10
97.7
body height
6
3
5
5.1
92.7
BMI-adjusted waist circumference
7
3
15
88.8
sex hormone-binding globulin measurement
5
3
5
87.9
body fat distribution
2
1
6
87.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
97.7
body height
5
5.1
92.7
BMI-adjusted waist circumference
15
88.8
sex hormone-binding globulin measurement
5
87.9
body fat distribution
6
87.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
histone H2B type 2-E
483169
Platypus
histone H2B type 2-E
100680750
Species
Name
OMA
EggNOG
Inparanoid
Dog
histone H2B type 2-E
Platypus
histone H2B type 2-E
Publication Statistics
PubMed Score 3819.62
PubMed score by year
PubTator Score 462.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text