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Tbio
HAGH
Hydroxyacylglutathione hydrolase, mitochondrial

Protein Summary
Description
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397353
  • ENSP00000380511
  • ENSG00000063854
  • ENST00000397356
  • ENSP00000380514
  • ENST00000455446
  • ENSP00000406552

Symbol
  • GLO2
  • HAGH1
  • GLO2
  • GLX2
  • GLXII
  • HAGH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.87
transcription factor binding site profile
0.87
transcription factor perturbation
0.84
virus perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxyacylglutathione hydrolase
453828
Macaque
hydroxyacylglutathione hydrolase
703206
Mouse
MGI:95745
14651
Rat
RGD:2779
24439
Dog
hydroxyacylglutathione hydrolase
VGNC:41585
479888
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxyacylglutathione hydrolase
Macaque
hydroxyacylglutathione hydrolase
Mouse
Rat
Dog
hydroxyacylglutathione hydrolase
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16775-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
GLO1
Tchem
Family: Enzyme
Novelty: 0.00225012
Score: 0.997
Data Source: STRINGDB
LDHD
Tbio
Family: Enzyme
Novelty: 0.0230704
Score: 0.916
Data Source: STRINGDB
GPA33
Tbio
Novelty: 0.0081206
Score: 0.802
Data Source: STRINGDB
ESD
Tbio
Family: Enzyme
Novelty: 0.00519384
Score: 0.783
Data Source: STRINGDB
ASIC4
Tbio
Family: IC
Novelty: 0.02912816
Score: 0.755
Data Source: STRINGDB
PARK7
Tbio
Family: Enzyme
Novelty: 0.00104651
Score: 0.685
Data Source: STRINGDB
SIGLEC12
Tbio
Novelty: 0.00914453
Score: 0.675
Data Source: STRINGDB
UBXN6
Tbio
Novelty: 0.08383376
Score: 0.665
Data Source: STRINGDB
CES5A
Tbio
Family: Enzyme
Novelty: 0.01165906
Score: 0.654
Data Source: STRINGDB
CES2
Tchem
Family: Enzyme
Novelty: 0.00177726
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  133.39

PubMed score by year
PubTator Score  146.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer